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  4. Recombinant Rat ATP-citrate synthase (Acly), partial

Recombinant Rat ATP-citrate synthase (Acly), partial

  • 中文名稱：
    Recombinant Rat ATP-citrate synthase(Acly) ,partial
  • 貨號：
    CSB-YP001158RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-citrate synthase(Acly) ,partial
  • 貨號：
    CSB-EP001158RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-citrate synthase(Acly) ,partial
  • 貨號：
    CSB-EP001158RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-citrate synthase(Acly) ,partial
  • 貨號：
    CSB-BP001158RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat ATP-citrate synthase(Acly) ,partial
  • 貨號：
    CSB-MP001158RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Acly; ATP-citrate synthase; EC 2.3.3.8; ATP-citrate; pro-S-)-lyase; Citrate cleavage enzyme
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
  • 基因功能參考文獻：
    1. ATP citrate lyase is important for the pyruvate citrate shuttle and lipid synthesis in insulin secretion. PMID: 23225248
    2. mRNAs of SCOT and ATP citrate lyase were decreased 55% and 58% and enzyme activities were decreased >70% in pancreatic islets of the GK rat, a model of type 2 diabetes. PMID: 20460097
    3. Results suggest that Sp1 acts on the ATP citrate lyase promoter to produce basal and induced transcription by low fat/high carbohydrate diets. PMID: 11989980
    4. ATP-citrate lyase is a protein kinase B substrate in adipocytes PMID: 12107176
    5. Normal flux through ATP-citrate lyase is not required for glucose-stimulated insulin secretion. PMID: 17823126
    6. expression in insulin-producing beta cells is linked to glucose-regulated insulin secretion PMID: 12086928

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  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Succinate/malate CoA ligase beta subunit family; Succinate/malate CoA ligase alpha subunit family
  • 組織特異性：
    Expressed in the brain, kidney, mammary gland, lung and liver.
  • 數(shù)據(jù)庫鏈接：