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  4. Recombinant Rat Coxsackievirus and adenovirus receptor homolog (Cxadr), partial

Recombinant Rat Coxsackievirus and adenovirus receptor homolog (Cxadr), partial

  • 中文名稱：
    Recombinant Rat Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-YP874156RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-EP874156RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-EP874156RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-BP874156RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Coxsackievirus and adenovirus receptor homolog(Cxadr),partial
  • 貨號：
    CSB-MP874156RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cxadr
  • Uniprot No.：
  • 別名：
    Cxadr; CarCoxsackievirus and adenovirus receptor homolog; CAR; rCAR
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
  • 基因功能參考文獻：
    1. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively PMID: 25497012
    2. CAR-positive cells are pituitary stem/progenitor cells and compose putative stem/progenitor cell niches in the MCL and parenchyma. PMID: 24057874
    3. CAR is not only a structural protein: it is involved in conferring the phosphorylation status of other adhesion proteins at the blood-testis barrier. PMID: 22875787
    4. is an integral membrane component of tight junction in podocytes and that CAR expression in podocytes is regulated at the transcriptional level and in the redistribution of protein PMID: 12808125
    5. coxsackievirus and adenovirus receptor (CAR) was expressed abundantly on the whole surface of cardiomyocytes in immature rat hearts PMID: 14624362
    6. CAR functions as an adhesion molecule in maintaining the inter-Sertoli cell junctions at the basal compartment of the seminiferous epithelium. In addition, CAR may confer adhesion between Sertoli and germ cells at the Sertoli-germ cell interface. PMID: 17359973
    7. expression of coxsackievirus and adenovirus receptor (CAR), the major receptor of coxsackievirus B5 (CVB5), was down-regulated in mature neurons; data support that level of CAR in neurons is a determinant in age-dependency of CBV5 virulence in CNS PMID: 18205224
    8. it is proposed that adenovirus CAV-2 transport in motor neuron is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis PMID: 19461877

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction.
  • 組織特異性：
    Expressed in heart, brain, spleen, lung, liver, muscle, kidney, testis, spleen and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：