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  4. Recombinant Rat Plasma kallikrein (Klkb1),Partial

Recombinant Rat Plasma kallikrein (Klkb1),Partial

In Stock
  • 中文名稱：
    大鼠Klkb1重組蛋白
  • 貨號：
    CSB-EP012461RA
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Klkb1; Klk3; PkPlasma kallikrein; EC 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Plasma kallikrein light chain
  • 來源：
    E.coli
  • 分子量：
    31.8kDa
  • 表達區(qū)域：
    391-638aa
  • 氨基酸序列
    IVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPDVWRIYGGILNLSEITNKTPFSSIKELIIHQKYKMSEGSYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYTKERGETQNILQKATIPLVPNEECQKKYRDYVITKQMICAGYKEGGIDACKGDSGGPLVCKHSGRWQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSSKERALETSPA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    This Recombinant Rat Plasma kallikrein (Klkb1) (partial) is the Plasma kallikrein light chain corresponding to the amino acid sequence of 391-638. E.coli-expressed recombinant Klkb1 protein was fused with an N-terminal 6xHis-tag. It has a high purity (>90%) measured by SDS-PAGE. Based on the below functions, this Klkb1 protein may find uses in the studies of Klkb1-targeted MS therapeutic development and research.

    Klkb1 is a specific direct regulator of blood-brain barrier (BBB) integrity. In the active central nervous system (CNS) lesions of patients with multiple sclerosis (MS), klkb1 precursor plasma kinin (PK) levels were significantly increased. PK deficiency or pharmacologic blockade makes the mice less prone to experimental autoimmune encephalomyelitis and is accompanied by a significant reduction of BBB destruction and CNS inflammation. Klkb1 inhibition can decrease cell invasion during neuroinflammation, which may provide a strategy against Ms.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Plasma kallikrein subfamily
  • 數(shù)據(jù)庫鏈接：