KLKB1
KLKB1，全稱為Kallikrein B1，也被稱為PKK、PPK、KLK3、PKKD。該蛋白參與血液凝固、纖維蛋白溶解、激肽生成和炎癥等過程。KLKB1與高分子量激肽原形成復(fù)合物，在凝血因子XII的激活下，將前原蛋白轉(zhuǎn)化為激肽釋放酶，進(jìn)而生成緩激肽。緩激肽參與血管通透性的調(diào)節(jié)、炎癥反應(yīng)以及內(nèi)源性凝血和纖溶過程。KLKB1蛋白的突變會(huì)導(dǎo)致前激肽原缺乏，引發(fā)遺傳性血管性水腫（HAE）。HAE是一種罕見的遺傳性疾病，患者體內(nèi)缺乏C1酯酶抑制物或其功能存在缺陷，導(dǎo)致皮膚和黏膜反復(fù)發(fā)生水腫。針對(duì)KLKB1的藥物研發(fā)主要集中在HAE的治療上。例如，KalVista公司開發(fā)的口服血漿激肽釋放酶（KLKB1）抑制劑Sebetralstat已獲得歐洲EMA的上市授權(quán)申請(qǐng)，用于按需治療HAE。此外，Rezolute公司的小分子KLKB1抑制劑RZ402也在臨床試驗(yàn)中顯示出良好的療效，用于治療糖尿病性黃斑水腫。這些藥物的研發(fā)為KLKB1相關(guān)疾病的治療提供了新的選擇。
熱銷產(chǎn)品
Recombinant Human Plasma kallikrein (KLKB1), partial (CSB-YP012461HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KLKB1 Recombinant Monoclonal Antibody (CSB-RA553053A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA553053A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Human plasma kallikrein(KLKB1) ELISA kit (CSB-E14339h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E14339h
規(guī)格：96T/48T
靈敏度：2.34 mU/mL
檢測(cè)范圍：9.38 mU/mL-600 mU/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
KLKB1 Antibodies
KLKB1 for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012461LD01RA | Klkb1 Antibody, Biotin conjugated | Rat | ELISA |
| CSB-PA012461LB01RA | Klkb1 Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA012461LA01RA | Klkb1 Antibody | Rat, Human | ELISA, WB |
| CSB-PA012461YA01RA | Klkb1 Antibody | Rat | ELISA |
| CSB-PA012461YB01RA | Klkb1 Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA012461YC01RA | Klkb1 Antibody, FITC conjugated | Rat | |
| CSB-PA012461YD01RA | Klkb1 Antibody, Biotin conjugated | Rat | ELISA |
KLKB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA000082 | Cleaved-KLKB1 (R390) Antibody | Human | WB, IHC, ELISA |
| CSB-PA012461LA01HU | KLKB1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA012461LB01HU | KLKB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012461LC01HU | KLKB1 Antibody, FITC conjugated | Human | |
| CSB-PA012461LD01HU | KLKB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA553053A0HU | KLKB1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
KLKB1 Proteins
KLKB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012461RA | Recombinant Rat Plasma kallikrein (Klkb1), partial | Yeast |
| CSB-EP012461RA | Recombinant Rat Plasma kallikrein (Klkb1),Partial | E.coli |
| CSB-BP012461RA CSB-MP012461RA CSB-EP012461RA-B |
Recombinant Rat Plasma kallikrein (Klkb1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLKB1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012461MO CSB-EP012461MO CSB-BP012461MO CSB-MP012461MO CSB-EP012461MO-B |
Recombinant Mouse Plasma kallikrein (Klkb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLKB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012461HU | Recombinant Human Plasma kallikrein (KLKB1), partial | Yeast |
| CSB-EP012461HU CSB-BP012461HU CSB-MP012461HU CSB-EP012461HU-B |
Recombinant Human Plasma kallikrein (KLKB1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLKB1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP643461BO CSB-EP643461BO CSB-BP643461BO CSB-MP643461BO CSB-EP643461BO-B |
Recombinant Bovine Plasma kallikrein (KLKB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLKB1 ELISA Kit
KLKB1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14339h | Human plasma kallikrein(KLKB1) ELISA kit | serum, plasma | 2.34 mU/mL |
KLKB1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16637m | Mouse plasma kallikrein(KLKB1) ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
KLKB1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012461RA | Rat Plasma kallikrein(KLKB1) ELISA kit | serum, plasma, tissue homogenates | 1.95 ng/mL |
