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  4. HEK293T/Mouse CDCP1 Stable Cell Line

HEK293T/Mouse CDCP1 Stable Cell Line

  • 貨號：
    CSB-SC719456MO1
  • 規(guī)格：
    1 vial contains approximately 5x106 cells in 1 ml
  • 價格：
    ￥30000
  • 活性：
    • Untransfected HEK293T cells (green line) and transfected Mouse Cdcp1 HEK293T stable cells (red line) were stained with anti-CDCP1 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 生長類型：
    Adherent
  • 抗性：
    Puromycin
  • 培養(yǎng)基：
    DMEM + 10% FBS + 2 μg/ml Puromycin
  • 別名：
    CDCP1
  • 蛋白標簽：
    N-terminal Flag-tagged
  • 保存緩沖液：
    35% FBS + 55% DMEM + 10% DMSO
  • 應用范圍：
    Binding assay by FACS and cell based ELISA.
  • 儲存條件：
    Frozen in liquid nitrogen or -80°C
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶點詳情

  • 功能：
    May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
  • 基因功能參考文獻：
    1. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases. PMID: 28760953
    2. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. PMID: 23243018
    3. established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 cleavage and PARP1-mediated apoptosis PMID: 22179830
    4. CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model PMID: 18483259
  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein.
  • 數(shù)據(jù)庫鏈接：