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MBP Monoclonal Antibody

  • 中文名稱(chēng)：
    MBP鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA000061M0m
  • 規(guī)格：
    ￥400
  • 圖片：
    • MBP-tagged fusion protein(20ng/ml) was subjected to SDS-PAGE followed by Western Blot with CSB-MA000061M0m at dilution of
      Lane 1:1000 Lane 4:8000 Lane 7:64000
      Lane 2:2000 Lane 5:16000 Lane 8:128000
      Lane 3:4000 Lane 6:32000 Lane 9:256000
      Secondary
      Goat polyclonal to Mouse IgG at 1/5000 dilution
      Predicted band size:50kd
      Observed band size:50kd
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MBP單克隆抗體（CUSABIO貨號(hào)：CSB-MA000061M0m）靶向髓鞘堿性蛋白（MBP），該蛋白是中樞神經(jīng)系統(tǒng)髓鞘的關(guān)鍵成分，參與神經(jīng)信號(hào)的高效傳導(dǎo)，在神經(jīng)發(fā)育、髓鞘形成及多發(fā)性硬化癥等脫髓鞘疾病研究中具有重要價(jià)值。本產(chǎn)品采用雜交瘤技術(shù)制備，具有高特異性與批次穩(wěn)定性，經(jīng)ELISA和Western Blot（WB）嚴(yán)格驗(yàn)證，適用于多種物種樣本檢測(cè)，能夠精準(zhǔn)識(shí)別天然和變性狀態(tài)下的MBP蛋白。在科研領(lǐng)域，該抗體可用于體外模型研究髓鞘再生機(jī)制、神經(jīng)退行性疾病病理分析，以及藥物開(kāi)發(fā)中的靶標(biāo)驗(yàn)證實(shí)驗(yàn)，為神經(jīng)生物學(xué)、免疫學(xué)及相關(guān)交叉學(xué)科提供可靠工具。通過(guò)優(yōu)化實(shí)驗(yàn)條件，研究者可高效完成蛋白互作分析、表達(dá)水平定量等基礎(chǔ)研究，助力神經(jīng)系統(tǒng)疾病機(jī)理的深入探索。
  • Uniprot No.：
  • 別名：
    Maltose Binding Protein, MBP, MBP Tag
  • 宿主：
    mouse
  • 反應(yīng)種屬：
    N/A
  • 免疫原：
    MBP-Tag fusion protein
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    monoclonal
  • 抗體亞型：
    IgG2a
  • 純化方式：
    >95%,Protein G purified
  • 克隆號(hào)：
    1E52C2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose.
  • 基因功能參考文獻(xiàn)：
    1. Upon refolding, MBP initially collapses into a dynamic molten globule-like ensemble, then forms an obligatory on-pathway native-like folding intermediate that brings together sequentially remote segments and then folds globally after a long delay. PMID: 29295923
    2. Our current understanding of what makes MBP such an effective solubility enhancer for other proteins and how it facilitates the proper folding of its fusion partners is presented [REVIEW] PMID: 28132493
    3. Maltose Binding Protein is key to the coupling of maltose transport to ATP hydrolysis in vivo, because it facilitates the progression of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyze ATP PMID: 26268698
    4. activates mouse macrophages and polarizes them into M1 macrophages PMID: 24825603
    5. a salt-bridge motif in the maltose-binding protein has a role in the initial steps of substrate transport PMID: 16143635
    6. Our findings indicate that the solubility-enhancing activity of MBP is mediated by its open conformation and point to a likely role for the ligand-binding cleft in the mechanism of solubility enhancement. PMID: 17964542
    7. These data indicate that unfolding of the mature domain of preMBP is likely not a rate-determining step in translocation when the protein is targeted to the translocase via SecB. PMID: 18241889
    8. tat mutants are able to transport maltose in the absence of malE. PMID: 18385983

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  • 亞細(xì)胞定位：
    Periplasm.
  • 蛋白家族：
    Bacterial solute-binding protein 1 family
  • 數(shù)據(jù)庫(kù)鏈接：