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  4. Recombinant Chicken Tyrosinase (TYR)

Recombinant Chicken Tyrosinase (TYR)

  • 中文名稱：
    雞TYR重組蛋白
  • 貨號：
    CSB-CF025394CH
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    TYR; Tyrosinase; Monophenol monooxygenase
  • 種屬：
    Gallus gallus (Chicken)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    19-529
  • 氨基酸序列
    QFPRVCANTQSLLRKECCPPWDGDGTPCGERSNRGTCQRILLSQAPLGPQFPFSGVDDREDWPSVFYNRTCRCRGNFMGFNCGECKFGFSGQNCTERRLRTRRNIFQLTISEKDKFLAYLNLAKNIPSKDYVIATGTYAQMNNGSNPMFRNINVYDLFVWMHYYASRDTLLGGSNVWRDIDFAHEAPGFLPWHRAFLLLWEREIQKITGDENFTIPYWDWRDAEDCVICTDEYMGGQHPTNPNLLSPASFFSSWQVICTQSEEYNSQQALCNATSEGPILRNPGNNDKSRTPRLPSSSEVEFCLTLTQYESGSMDKMANYSFRNTLEGFADPHTAISNISQSGLHNALHIYMNGSMSQVQGSANDPIFILHHAFVDSIFERWLRRHRPMLEVYPAANAPIGHNRENYMVPFIPLYRNGEFFISSRELGYDYEYLQEPALGSFQDFLIPYLKQAHQIWPWLVGAAVIGGIITAVLSGLILACRKKRKGTSPEIQPLLTESEDYNNVSYQSHF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
  • 基因功能參考文獻：
    1. Individuals with genotypes AA and AT had greater TYR expression than those with genotype TT. A luciferase assay of the promoter activity revealed that genotype AA had greater activity than genotype TT. PMID: 29050424
    2. The co-segregation of plumage coloration and sequence polymorphism in TYR and MC1R genes were investigated using an intercross between black and white plumage color types of the Dongxiang blue-shelled chicken. PMID: 20460655
    3. This study provided original information for elucidating the possible roles of exon-1 of TYR gene and 5' flanking region in chickens with different flesh color chicken. PMID: 19437131
    4. Mutated proteins showed the insertion of a complete avian retroviral sequence of the Avian Leukosis Virus (ALV) family. PMID: 16457736
    5. An avian retroviral sequence insertion in the tyrosinase gene was the cause of recessive white phenotype in chickens. PMID: 17878441

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  • 亞細胞定位：
    Melanosome membrane; Single-pass type I membrane protein. Melanosome.
  • 蛋白家族：
    Tyrosinase family
  • 數(shù)據(jù)庫鏈接：