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TYR

酪氨酸酶（TYR）是黑色素合成的核心催化劑，又稱多酚氧化酶，廣泛存在于皮膚、毛發(fā)等組織的黑色素細(xì)胞中。它通過促使酪氨酸轉(zhuǎn)化為多巴醌，推動(dòng)黑色素顆粒的形成，直接影響生物體膚色與紫外線防護(hù)能力。該蛋白活性異常與多種疾病密切相關(guān)：先天性TYR功能缺陷會(huì)導(dǎo)致眼皮膚白化病，患者表現(xiàn)為皮膚、毛發(fā)色素缺失及視力障礙；而TYR過度激活則與惡性黑色素瘤、黃褐斑等色素沉著性疾病相關(guān)。近年來，針對TYR的抑制劑成為化妝品和皮膚病藥物研發(fā)熱點(diǎn)，熊果苷、曲酸等天然成分已應(yīng)用于美白產(chǎn)品，新型小分子化合物如硫脲衍生物、金屬螯合劑等進(jìn)入臨床試驗(yàn)階段。值得一提的是，部分抗癌藥物通過調(diào)控TYR表達(dá)來抑制黑色素瘤轉(zhuǎn)移，而基于蛋白結(jié)構(gòu)的靶向藥物設(shè)計(jì)也為治療遺傳性白化病提供了新思路。當(dāng)前研究不僅關(guān)注TYR的催化功能，還探索其在神經(jīng)保護(hù)、免疫調(diào)節(jié)中的潛在作用，這為跨疾病領(lǐng)域的治療策略開辟了新方向。

熱銷產(chǎn)品

Recombinant Human Tyrosinase (TYR), partial (CSB-YP025394HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TYR Recombinant Monoclonal Antibody (CSB-RA567167A0HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of MCF7 Cells with CSB-RA567167A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Human Tyrosinase(TYR) ELISA kit (CSB-EL025394HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL025394HU

規(guī)格：96T/48T

靈敏度：3.9 pg/mL

檢測范圍：15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TYR Antibody

TYR Protein

TYR ELISA Kit

TYR Antibodies

TYR for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA025394LA01HU	TYR Antibody	Human	ELISA, IHC, IF
CSB-PA025394LB01HU	TYR Antibody, HRP conjugated	Human	ELISA
CSB-PA025394LC01HU	TYR Antibody, FITC conjugated	Human
CSB-PA025394LD01HU	TYR Antibody, Biotin conjugated	Human	ELISA
CSB-PA589649	Tyrosinase Antibody	Human	WB
CSB-PA004353	TYR Antibody	Human,Monkey	WB, ELISA
CSB-PA112776	TYR Antibody	Human,Mouse	ELISA,WB
CSB-PA986893	TYR Antibody	Human,Mouse	ELISA,WB,IHC
CSB-RA567167A0HU	TYR Recombinant Monoclonal Antibody	Human	ELISA, IF

TYR Proteins

TYR Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394MO1 CSB-EP025394MO1 CSB-BP025394MO1 CSB-MP025394MO1 CSB-EP025394MO1-B	Recombinant Mouse Tyrosinase (Tyr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF025394MO	Recombinant Mouse Tyrosinase (Tyr)	in vitro E.coli expression system

TYR Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394HU	Recombinant Human Tyrosinase (TYR), partial	Yeast
CSB-EP025394HU	Recombinant Human Tyrosinase (TYR), partial	E.coli
CSB-BP025394HU CSB-MP025394HU CSB-EP025394HU-B	Recombinant Human Tyrosinase (TYR), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-BP025394HU2	Recombinant Human Tyrosinase (TYR), partial	Baculovirus

TYR Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394CH1 CSB-EP025394CH1 CSB-BP025394CH1 CSB-MP025394CH1 CSB-EP025394CH1-B	Recombinant Chicken Tyrosinase (TYR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF025394CH	Recombinant Chicken Tyrosinase (TYR)	in vitro E.coli expression system

TYR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394DO1 CSB-EP025394DO1 CSB-BP025394DO1 CSB-MP025394DO1 CSB-EP025394DO1-B	Recombinant Dog Tyrosinase (TYR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF025394DO	Recombinant Dog Tyrosinase (TYR)	in vitro E.coli expression system

TYR Proteins for Felis catus (Cat) (Felis silvestris catus)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394CA CSB-EP025394CA CSB-BP025394CA CSB-MP025394CA CSB-EP025394CA-B	Recombinant Cat Tyrosinase (TYR)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TYR Proteins for Pelophylax nigromaculatus (Black-spotted frog) (Rana nigromaculata)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394PEM1 CSB-EP025394PEM1 CSB-BP025394PEM1 CSB-MP025394PEM1 CSB-EP025394PEM1-B	Recombinant Pelophylax nigromaculatus Tyrosinase (TYR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF025394PEM	Recombinant Pelophylax nigromaculatus Tyrosinase (TYR)	in vitro E.coli expression system

TYR Proteins for Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394PEL CSB-EP025394PEL CSB-BP025394PEL CSB-MP025394PEL CSB-EP025394PEL-B	Recombinant Pelodiscus sinensis Tyrosinase (TYR)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TYR Proteins for Oryzias latipes (Medaka fish) (Japanese ricefish)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP025394OFH1 CSB-EP025394OFH1 CSB-BP025394OFH1 CSB-MP025394OFH1 CSB-EP025394OFH1-B	Recombinant Oryzias latipes Tyrosinase (tyr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF025394OFH	Recombinant Oryzias latipes Tyrosinase (tyr)	in vitro E.coli expression system

TYR Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP600102DXJ CSB-EP600102DXJ CSB-BP600102DXJ CSB-MP600102DXJ CSB-EP600102DXJ-B	Recombinant Coturnix coturnix japonica Tyrosinase (TYR)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TYR Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP818647BO CSB-EP818647BO CSB-BP818647BO CSB-MP818647BO CSB-EP818647BO-B	Recombinant Bovine Tyrosinase (TYR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TYR Proteins for Gorilla gorilla gorilla (Lowland gorilla)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP860196GGZ CSB-EP860196GGZ CSB-BP860196GGZ CSB-MP860196GGZ CSB-EP860196GGZ-B	Recombinant Gorilla gorilla gorilla Tyrosinase (TYR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli