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  4. Recombinant Dog Occludin (OCLN)

Recombinant Dog Occludin (OCLN)

  • 中文名稱：
    熟悉的犬OCLN重組蛋白
  • 貨號：
    CSB-CF016263DO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    OCLN; Occludin
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-521
  • 氨基酸序列
    MSSRPFESPPPYRPDEFKPNHYAPSNDVYGGDMHVRPMLSQPAYSFYPEDEILHFYKWTS PPGVIRILSMLVIVMCIAIFGCVASTLAWDRGYGTGLMGGSIGYPYGSGFGSYGTGYGYG FGYGYGYGGYTDPRAAKGFLLAMVAFCFIAALVIFVTSVIRSDISRTRRYYLTVIILSAF LGVMMFIATIVYIMGVNPTAQASGSLYSSQIYAMCNQFYASTATGLYMDQYLYHYCVVDP QEAIAIVLGFMVIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNV SAGTQDMPPPPSDYVERVDSPMAYSSNGKVNDKRLYPESSYKSTPVPEVVQELPATSPAD DFRQPRYSSSGHLEPPSKRAPSKGRTGRPKRLEQDHYETDYTTGGESCDELEEDWIREYP PITSDQQRQLYKRNFDTGLQEYKSLQAELDEINKELSRLDKELDDYREESEEYMAAADEY NRLKQVKGSPDYKNKRNYCKQLKSKLSHIKKMVGDYDRQKT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1.
  • 基因功能參考文獻：
    1. In the present study, organspecific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney. PMID: 27600198
    2. Occludin and ZO-1 expression remained unchanged between atopic and clinically normal dogs. PMID: 25673908
    3. EhCP112 and EhADH112 co-localize with occludin and claudin-1 at tight junctions. PMID: 23762290
    4. occludin has a role in centrosome separation and mitosis PMID: 21757728
    5. The 41- and 48-kDa C-terminal occludin fragments formed during cholesterol depletion result from the action of a GM6001-sensitive metalloproteinase(s) at some point in the path leading to release of the membrane particles. PMID: 19854171
    6. Removing Cholesterol from the plasma membrane increased tyrosine and threonine phosphorylation of occludin, and transepithelial electrical resistance (TER). PMID: 17574235
    7. Knockdown of occludin caused mislocalization of tricellulin to bTJs, implying that occludin supports tricellular localization of tricellulin by excluding tricellulin from bicellular tight junctions. PMID: 18768749
    8. a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues. PMID: 19017651
    9. Elevated expression of p110 CUX1 causes loss of E-cadherin and Occludin from cell-cell junctions PMID: 19635798

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
  • 蛋白家族：
    ELL/occludin family
  • 組織特異性：
    Localized at tight junctions of both epithelial and endothelial cells.
  • 數據庫鏈接：