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  4. Recombinant High-energy light unresponsive protein 1 (lite-1)

Recombinant High-energy light unresponsive protein 1 (lite-1)

  • 中文名稱：
    秀麗隱桿線蟲lite-1重組蛋白
  • 貨號：
    CSB-CF623148CXY
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    lite-1
  • Uniprot No.：
  • 別名：
    lite-1; gur-2; C14F11.3; High-energy light unresponsive protein 1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-439
  • 氨基酸序列
    MPPPSSHSNIFHSTFKHTVKETMANAKKTMIAKILSSRNKWAICDRTLYPIYYLLLILGL NQSIRPNNSLLFRIYSWLVFCLLLFTTLRKFNQVGVRPNGTRENLQEFFANPRSMITLCN ALIMLSGLLASLQLYTLGAKRLKPLKILCQFSLNVRTKQAERRQFMINTFLAVFSGLLAL TMAATYAMSKWGYILYIVGTPNLDTETIFCVLLDSYALFVSRAAISALAILFYQHCSVIR RSIKHLINEMVPAEQDECPLPESSLQKIHDCQISYQRIFNGKAVIEEYYSFVLFYSYGVC IPIFCFLMFVGMSAQSICWSEVVSIVIWIVNAILVLLLFSLPAFMINEDGDRLVASSFRM YHETFHEERDLTVLSQMTFFTFQIHSTKLTLSACNYFYMDRSILLSLFSAILTYFLILWE FDIKNNQSLQNIANHTIHT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. Might have a role in response to white light exposure.
  • 基因功能參考文獻：
    1. Unlike typical photoreceptors employing a prosthetic chromophore to capture photons, LITE-1 strictly depends on its protein conformation for photon absorption; further two tryptophan residues critical for LITE-1 function were identified. Interestingly, unlike GPCRs, LITE-1 adopts a reversed membrane topology. Thus, LITE-1, a taste receptor homolog, represents a distinct type of photoreceptor in the animal kingdom. PMID: 27863243
    2. receptor family members LITE-1 and GUR-3 are required for the inhibition of feeding by light and hydrogen peroxide. PMID: 25640076
    3. data suggest a model in which LITE-1 transduces light signals in a photoreceptor neuron via G protein signaling, leading to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptors PMID: 20436480
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Insect chemoreceptor superfamily, Gustatory receptor (GR) family
  • 組織特異性：
    Expressed in the AVG and PVT neurons of the tail.
  • 數(shù)據(jù)庫鏈接：

    KEGG: cel:CELE_C14F11.3

    STRING: 6239.C14F11.3

    UniGene: Cel.802