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  4. Recombinant Human Transmembrane protein 18 (TMEM18)

Recombinant Human Transmembrane protein 18 (TMEM18)

  • 中文名稱：
    人TMEM18重組蛋白
  • 貨號：
    CSB-CF023763HU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    TMEM18
  • Uniprot No.：
  • 別名：
    TMEM18; Transmembrane protein 18
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-140
  • 氨基酸序列
    MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCLSSRSYRLQIGHFLCLV ILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLLVNAMIIVVMWVWKTLNVM TDLKNAQERRKEKKRRRKED
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).
  • 基因功能參考文獻：
    1. Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes PMID: 27005443
    2. Studies indicate association of transmembrane protein 18 (TMEM18) variants within the proximal haplotype block with obesity and body mass. PMID: 26365393
    3. rs186019316 and rs7596758 in TMEM18 is associated with body mass index. PMID: 24951660
    4. TMEM18 mRNA expression levels are related to phenotypes of obesity and glucose metabolism. PMID: 24763707
    5. In summary, moderately rare missense variants within the...TMEM18 genes observed in our study did not confer risk of common childhood obesity in African Americans... PMID: 23505181
    6. Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. PMID: 23229156
    7. TMEM18rs6548238 associated with risk of diabetes after adjustment for body mass index. PMID: 22466342
    8. Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005 PMID: 21750520
    9. The polymorphisms rs6548238 and rs9935401 showed no association with educational level or income. PMID: 20628085
    10. Our data suggest that SNPs in or near the TMEM18 locus contribute to obesity risk in the Greek population. PMID: 21720444
    11. We observed a strong positive correlation between TMEM18 expression and body weight in the prefrontal cortex (PFC) (r = 0.5694, P = 0.0003) indicating a potential role for TMEM18 in higher functions related to feeding involving the PFC. PMID: 21952719
    12. TMEM18 localises to the nuclear membrane and binds to DNA in a sequence-specific manner: perhaps this closed perinuclear localisation of TMEM18-bound DNA might repress transcription from it. PMID: 21980424
    13. The risk allele TMEM18 rs6548238 was associated with bodym mass index, higher waist circumference and total body fat. PMID: 19910938
    14. TMEM18 is involved in both adult and childhood obesity and found in the majority of all brain sites, including the hypothalamus and the brain stem. PMID: 20380707
    15. Overexpression of TMEM18 is associated with glioma PMID: 18559506

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  • 亞細胞定位：
    Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMEM18 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25257

    OMIM: 613220

    KEGG: hsa:129787

    STRING: 9606.ENSP00000281017

    UniGene: Hs.43899