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  4. Recombinant Human Tripartite motif-containing protein 59 (TRIM59)

Recombinant Human Tripartite motif-containing protein 59 (TRIM59)

  • 中文名稱：
    人TRIM59重組蛋白
  • 貨號(hào)：
    CSB-CF808999HU
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    TRIM59; RNF104; TRIM57; TSBF1; Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-403
  • 氨基酸序列
    MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLKCPNCR SITEIAPTGIESLPVNFALRAIIEKYQQEDHPDIVTCPEHYRQPLNVYCLLDKKLVCGHC LTIGQHHGHPIDDLQSAYLKEKDTPQKLLEQLTDTHWTDLTHLIEKLKEQKSHSEKMIQG DKEAVLQYFKELNDTLEQKKKSFLTALCDVGNLINQEYTPQIERMKEIREQQLELMALTI SLQEESPLKFLEKVDDVRQHVQILKQRPLPEVQPVEIYPRVSKILKEEWSRTEIGQIKNV LIPKMKISPKRMSCSWPGKDEKEVEFLKILNIVVVTLISVILMSILFFNQHIITFLSEIT LIWFSEASLSVYQSLSNSLHKVKNILCHIFYLLKEFVWKIVSH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May serve as a multifunctional regulator for innate immune signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. TRIM59 expression is upregulated in hepatocellular carcinoma (HCC) cells; TRIM59 promotes cell proliferation, migration and invasion in HCC cells PMID: 29442042
    2. The level of TRIM59 is correlated with malignant features of colorectal carcinoma (CRC)and may serve as potential therapeutic and preventive strategies for CRC PMID: 28849218
    3. Knockdown of TRIM59 may be a promising strategy concerning the early detection and treatment of Renal cell carcinoma. PMID: 28719348
    4. TRIM59 overexpression is associated with colorectal cancer metastasis. PMID: 28534983
    5. our results suggest that rs1141023 polymorphism contributes to increased predisposition to gastric cancer PMID: 28009992
    6. The expression of TRIM59 was significantly elevated in cervical cancers. PMID: 27662486
    7. These data suggest the oncogenic abilities of TRIM59 in osteosarcoma, which promote osteosarcoma cell proliferation, migration and invasion PMID: 27121462
    8. we knocked down TRIM59 and found that p53 protein expression levels did not upregulate, so we proposed that TRIM59 may promote NSCLC cell growth through other pathways but not the p53 signaling pathway PMID: 26599082
    9. TRIM59 interacts with P53, promoting its ubiquitination and degradation, and TRIM59 might promote gastric carcinogenesis via this mechanism. PMID: 25046164
    10. These findings indicate that TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways. PMID: 22588174
    11. PMID:12095697 pertains to mouse Mrf1 gene which appears to be the homolog of human TSBF1. PMID: 12095697

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    TRIM/RBCC family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30834

    OMIM: 616148

    KEGG: hsa:286827

    STRING: 9606.ENSP00000311219

    UniGene: Hs.212957