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  4. Recombinant Mouse Somatostatin receptor type 3 (Sstr3)

Recombinant Mouse Somatostatin receptor type 3 (Sstr3)

  • 中文名稱：
    小鼠Sstr3重組蛋白
  • 貨號：
    CSB-CF022726MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Sstr3
  • Uniprot No.：
  • 別名：
    Sstr3; Smstr3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-428
  • 氨基酸序列
    MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGL LGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLV MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVV VFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRR VRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAF FGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEE EDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGD KASTLSHL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
  • 基因功能參考文獻：
    1. results implicate beta-arrestin in the modulation of Sstr3 ciliary localization and further suggest a role for beta-arrestin in the mediation of Sstr3 ciliary signaling. PMID: 26503786
    2. Both Sstr3 (and SStr2) receptors are required for the anticonvulsant effects mediated by cortistatin-14. PMID: 24685142
    3. SSTR3 immunoreactivity increases in ApoD(-/-) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle. PMID: 22581439
    4. Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers. PMID: 23029470
    5. this novel finding that Rab21 regulates SSTR3 trafficking suggests that Rab21 may play a role in trafficking of other GPCRs. PMID: 21925142
    6. somatostatin receptor 3 expression was restricted to the plasma membrane of cilia in insulin- and growth hormone-secreting cells of the mouse, differing from previously reported immunohistochemical localization in cell bodies PMID: 21383513
    7. Receptor coupling to adenylyl cyclase is disrupted upon Sstr3 C-tail deletions. PMID: 21194548
    8. From the data of this study shown that somatostatin receptor 3 is critical for object recognition memory. PMID: 20335466
    9. The effect of sst2 receptor knockout on sst3 receptor mRNA localization and binding sites throughout the brain has been determined. PMID: 11897118
    10. Expression of SSTR3, SSTR4, and SSTR5 in mouse proximal tubules complements the expression of SSTR1 and SSTR2 in collecting ducts as seen in other species. PMID: 12472768
    11. a lack of ciliary localization of somatostatin receptor type 3 (Sstr3) and melanin-concentrating hormone receptor 1 (Mchr1) in neurons from mice lacking the Bbs2 or Bbs4 gene PMID: 18334641

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of t
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