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  4. Recombinant Mouse Syntaxin-1A (Stx1a)

Recombinant Mouse Syntaxin-1A (Stx1a)

  • 中文名稱：
    小鼠Stx1a重組蛋白
  • 貨號：
    CSB-CF022895MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Stx1a; Syntaxin-1A; Neuron-specific antigen HPC-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-288
  • 氨基酸序列
    MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLETSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIIIASTIGGIFG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).
  • 基因功能參考文獻(xiàn)：
    1. The role of syntaxin 1A in GLP1 release from intestinal cells as a response to external stimuli is reported. PMID: 28596237
    2. Therefore, our work provides insights into differential functions of Stx1 in neuronal maintenance and neurotransmission, with the latter explored further into its functions in vesicle docking and fusion. PMID: 27466336
    3. Syn-1A actions on newcomer SGs were partly mediated by Syn-1A interactions with newcomer SG VAMP8 PMID: 28031464
    4. The results of this study suggested that STX1A plays an important role in social behavior through regulation of the OXTergic neural system. PMID: 27059771
    5. syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes PMID: 24604356
    6. Although STX1A and STX1B share a basic function as neuronal t-SNAREs, STX1B but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission. PMID: 24587181
    7. we found that STX1A and STX1B play distinct roles in neuronal survival using PMID: 24666284
    8. point mutation in syntaxin-1A causes abnormal regulation of neuronal plasticity and vesicle recycling and that the affected syntaxin-1A/CaMKII interaction is essential for normal brain and synaptic functions in vivo. PMID: 24136198
    9. overall release efficiency of affected hippocampal neurons was severely impaired by reducing levels of Stx1, as demonstrated by a smaller readily releasable pool size, slower refilling rate of primed vesicles, and lower release probability. PMID: 24133272
    10. CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. PMID: 23801330
    11. The N-terminal syntaxin-1 domains mediate different functions in synaptic vesicle fusion, probably via formation of distinct Munc18/SNARE-protein complexes. PMID: 23188083
    12. Direct interaction between syntaxin 1A and the Kv2.1 C-terminus is required for efficient insulin exocytosis and glucose-stimulated insulin secretion. PMID: 22411134
    13. Nesca directly binds KIF5B, kinesin light-chain and syntaxin-1 PMID: 22404429
    14. Sytaxin 1A may be involved in rearrangement of synaptic connections between neurons in the spinal dorsal horn induced by peripheral nerve injury. PMID: 21129445
    15. Lack of STX1A could induce dysfunction of the HPA axis, and the deficit may result in abnormal behavioural properties, such as unusual responses to stress stimuli. PMID: 21910766
    16. HPC-1/syntaxin 1A regulates catecholaminergic systems via exocytosis of dense-core synaptic vesicles. Deletion of HPC-1/syntaxin 1A causes impairment of long term potentiation induction. PMID: 22219298
    17. Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A. PMID: 21884702
    18. STX1A may play a role in the structural formation of the inner nuclear layer and outer plexiform layer in the retina. PMID: 21822613
    19. granuphilin binds to syntaxin-2 and syntaxin-3 as well as syntaxin-1a, it likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane. PMID: 21768089
    20. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1. PMID: 21173146
    21. Data show that ablation of syntaxin 1A may cause disruption of 5-HT-ergic transmission and induce abnormal behavior. PMID: 20576034
    22. syntaxin 1a has a role in granuphilin promotion of plasma membrane targeting of insulin granules PMID: 15028737
    23. These data demonstrate that the Munc18-1 interaction with syntaxin 1 is physiologically important, but does not represent a classical chaperone-substrate relationship. PMID: 15935055
    24. Our data indicate that htt(exon1) enhances calcium influx by blocking syntaxin 1A inhibition of N-type calcium channels and attributes a key role for htt N-terminal fragments in the fine tuning of neurotransmission. PMID: 16162412
    25. These observations suggest that HPC-1/syntaxin 1A may be closely related to synaptic plasticity PMID: 16723534
    26. the interaction of Sept5 with syntaxin-1 is regulated by the phosphorylation of Sept5_v1 at Ser17 by Cdk5-p35 PMID: 17224448
    27. HPC-1/syntaxin 1A might play a role in synaptic plasticity in the nociceptive pathway. PMID: 17953616
    28. Stx1a interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. PMID: 18617632
    29. syntaxin 1A is an important regulator of normal in utero development, but may not be essential for normal brain function later in life. PMID: 18713622
    30. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.( PMID: 19129200

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  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane.
  • 蛋白家族：
    Syntaxin family
  • 組織特異性：
    Present in the ileum.
  • 數(shù)據(jù)庫鏈接：