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  4. Recombinant Rat Aquaporin-6 (Aqp6)

Recombinant Rat Aquaporin-6 (Aqp6)

  • 中文名稱：
    Recombinant Rat Aquaporin-6(Aqp6)
  • 貨號(hào)：
    CSB-CF894353RA
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Aqp6
  • Uniprot No.：
  • 別名：
    Aqp6; Aquaporin-6; AQP-6
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-276
  • 氨基酸序列
    MEPGLCNRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQVAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAVAYIAAQLAGATVGAALLYGVTPGGVRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDSRQTLGSPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTEVSV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
  • 基因功能參考文獻(xiàn)：
    1. confirmed AQP6 expression in retinal ganglion cells and Muller cells in vitro PMID: 26526333
    2. AQP6 is involved in osmoregulation to maintain both the acid-base and osmotic balance of parotid secretory granules. PMID: 23183829
    3. AQP6 labeling of the outer plexiform layer was decreased in retinal slices from diabetic rats in comparison to slices from control rats. PMID: 21851171
    4. Aquaporin 6 is localized in glial membranes that surround the ribbon synapses in the outer plexiform layer of retina. PMID: 21185908
    5. the primary role of AQP6 may be in cellular regulation PMID: 12177001
    6. Data show that a single residue substitution totally eliminates the anion permeability of aquaporin 6 when expressed in Xenopus oocytes, but these oocytes exhibit significantly higher osmotic water permeability under basal conditions. PMID: 15671159
    7. The results suggest that AQP6 participates in water and anion transport in plasma membranes near tight junctions and in secretory granule membranes in rat parotid acinar cells. PMID: 18188600
    8. aquaporin-6 is distributed throughout the gastrointestinal tract. Its localization at the apical pole of superficial epithelial cells and its upregulation by feeding suggest it may be involved in movements of water and anions through villi epithelium. PMID: 19811639

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  • 亞細(xì)胞定位：
    Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 組織特異性：
    Kidney.
  • 數(shù)據(jù)庫(kù)鏈接：