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  4. Recombinant Rat Myelin protein P0 (Mpz)

Recombinant Rat Myelin protein P0 (Mpz)

  • 中文名稱：
    大鼠Mpz重組蛋白
  • 貨號：
    CSB-CF014774RA
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Mpz
  • Uniprot No.：
  • 別名：
    Mpz; P0; Myelin protein P0; Myelin peripheral protein; MPP; Myelin protein zero
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    30-248
  • 氨基酸序列
    IVVYTDREVYGAVGSQVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPSWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGILGVVLLLLLLFYLIRYCWLRRQAALQRRLSAMEKGKFHKSSKDSSKRGRQTPVLYAMLDHSRSTKAASEKKSKGLGESRKDKK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
  • 基因功能參考文獻：
    1. that phylogenetic emergence of L-MPZ in amphibians may be related to particular distribution and/or function in the PNS myelin PMID: 29081003
    2. steady-state levels of insulin receptor mRNA increase during development and after postnatal day 10, when the peak of myelin structural gene (P0) expression occurs, increasing further in parallel with the growth of the myelin sheath PMID: 22564491
    3. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. PMID: 22457349
    4. The P0 in sciatic nerve of rats could be destroyed by 2,5-hexanedione and P0 expression level decreased with the time of 2,5-hexanedione administration. PMID: 20568451
    5. a rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo PMID: 21179557
    6. These results provided interesting experimental evidence for understanding the mechanism of demyelinating neuropathies caused by MPZ gene malfunction. PMID: 20552241
    7. Data show that the removal of circulating androgens by orchidectomy induces a significant decrease of the synthesis of glycoprotein Po and peripheral myelin protein 22 in the rat sciatic nerve. PMID: 15207917
    8. Data show that steroid receptor coactivator-1 (SRC-1) overexpressing cells are more responsive to Po mRNA induction by dihydroprogesterone (DHP) than SRC-1-deficient cells, and that DHP treatment increases not only Po but also SRC-1 mRNA levels. PMID: 15456935
    9. Our results suggest that this loss of adhesion may be due, at least in part, to a failure of sufficient MPZ to reach the cell surface and that this impaired trafficking is associated with deficient serine phosphorylation in the cytoplasmic domain. PMID: 16493674
    10. Myelin protein zero (P0) contains a hierarchy of targeting signals which may contribute to P0 localization in myelinating Schwann cells and disease pathogenesis. PMID: 16788992
    11. neuropathy-associated Egr2 mutants antagonize binding of Sox10 at specific sites, thereby disrupting genetic control of the myelination program PMID: 17325040

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Myelin P0 protein family
  • 組織特異性：
    Found only in peripheral nervous system Schwann cells.
  • 數(shù)據(jù)庫鏈接：