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  4. Recombinant Rat NADPH oxidase 3 (Nox3)

Recombinant Rat NADPH oxidase 3 (Nox3)

  • 中文名稱：
    大鼠Nox3重組蛋白
  • 貨號：
    CSB-CF015960RA
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Nox3
  • Uniprot No.：
  • 別名：
    Nox3; NADPH oxidase 3
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-568
  • 氨基酸序列
    MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWARASAVC LNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAH LFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVI SLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVT FCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQEVVITKVVS HPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWT EALLKAFGAEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKS VWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTG WDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAM SKTLQKMCRLYSSSDPRGVHFYYNKENF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
  • 基因功能參考文獻：
    1. These results suggested that the high expression levels of NOX3 increased oxidative stress in stroke-prone hypertensive rat cerebrum. PMID: 26830484
    2. NOX3 regulates stress-related genes in the cochlea, such as TRPV1 and KIM-1, and initiates apoptosis in the cochlea. PMID: 20214492
    3. NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs. PMID: 15326186
  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in the inner ear by the spiral glanglia and the organ of Corti.
  • 數(shù)據(jù)庫鏈接：