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ACKR1

ACKR1,即非典型趨化因子受體1,別名FY、Dfy、GPD、DARC、GpFy、CCBP1、CD234、WBCQ1、DARC/ACKR1等。ACKR1由人類ACKR1基因編碼,該基因位于1號染色體的1q23.2區(qū)域。ACKR1主要通過結(jié)合、內(nèi)化和降解趨化因子來調(diào)節(jié)免疫反應(yīng),作為一種“沉默”的清除受體,它不通過G蛋白發(fā)出信號,而是通過捕獲趨化因子來調(diào)節(jié)其在循環(huán)中的生物可用性,防止過度的循環(huán)趨化因子濃度和系統(tǒng)性白細胞激活,同時也為趨化因子提供血液儲備(緩沖),延長其半衰期。ACKR1在調(diào)節(jié)炎癥反應(yīng)和白細胞遷移中起著重要作用,其表達的缺失或變異與特定人群對瘧疾的抵抗力有關(guān),也與某些血液疾病相關(guān)。

熱銷產(chǎn)品

Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) (CSB-CF624105HU)

驗證數(shù)據(jù)

CSB-CF624105HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/ml can bind human CCL2, the EC50 of human CCL2 protein is 48.64-60.24 μg/ml.

CSB-CF624105HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DARC Recombinant Monoclonal Antibody (CSB-RA287686A0HU)

驗證數(shù)據(jù)

CSB-RA287686A0HU

Overlay Peak curve showing 293 cells stained with CSB-RA287686A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

ACKR1 Antibodies

ACKR1 for Homo sapiens (Human)

ACKR1 Proteins

ACKR1 Proteins for Homo sapiens (Human)

ACKR1 Proteins for Bos indicus (Zebu)

ACKR1 Proteins for Papio hamadryas (Hamadryas baboon)

ACKR1 Proteins for Saguinus imperator (Emperor tamarin)

ACKR1 Proteins for Cebus apella (Brown-capped capuchin)

ACKR1 Proteins for Pan troglodytes (Chimpanzee)

ACKR1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

ACKR1 Proteins for Macaca mulatta (Rhesus macaque)

ACKR1 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

ACKR1 Proteins for Bos taurus (Bovine)

ACKR1 Proteins for Mus musculus (Mouse)