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ACVR2A

ACVR2A,即激活素A型II型受體A,別名ACVR2、ACTRII。它是由ACVR2A基因編碼的跨膜絲氨酸/蘇氨酸激酶受體,屬于轉(zhuǎn)化生長(zhǎng)因子-β(TGF-β)超家族。ACVR2A主要在多種組織中表達(dá),如皮膚和膽囊。其作用機(jī)制涉及與激活素A結(jié)合后,招募并磷酸化I型激活素受體,通過SMAD2/3蛋白發(fā)出信號(hào),進(jìn)而影響細(xì)胞命運(yùn)。ACVR2A對(duì)組織再生、細(xì)胞分化和腫瘤發(fā)展等過程具有重要影響。ACVR2A在某些類型的癌癥中表達(dá)下調(diào),可能與腫瘤的轉(zhuǎn)移潛能和患者的預(yù)后相關(guān)。

熱銷產(chǎn)品

Recombinant Human/Cynomolgus Activin receptor type-2A (ACVR2A), partial (Active) (CSB-MP001260HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP001260HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP001260HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2A at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC50 is 3.848-4.375 ng/mL.

Recombinant Mouse Activin receptor type-2A (Acvr2a), partial (Active) (CSB-MP001260MO1)

驗(yàn)證數(shù)據(jù)

CSB-MP001260MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP001260MO1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Acvr2a at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC50 is 1.562-1.966 ng/mL.

CSB-MP001260MO1

The purity of ACVR2A was greater than 95% as determined by SEC-HPLC

ACVR2A&ACVR2B Recombinant Monoclonal Antibody (CSB-RA623829MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA623829MA1HU

The Binding Activity of Human ACVR2A with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2A(CSB-MP001260HU1)at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody . The EC50 is 3.848-4.375 ng/mL.

CSB-RA623829MA1HU

The Binding Activity of Mouse ACVR2A with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse ACVR2A(CSB-MP001260MO1) at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody. The EC50 is 1.562-1.966 ng/mL.

CSB-RA623829MA1HU

The Binding Activity of Mouse Acvr2b with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Acvr2b(CSB-MP001261MO1) at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody. The EC50 is 3.560-4.235 ng/mL.

CSB-RA623829MA1HU

The Binding Activity of Human ACVR2B with Anti-ACVR2A&ACVR2B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B(CSB-MP623829HU) at 2 μg/mL can bind Anti-ACVR2A&ACVR2B recombinant antibody. The EC50 is 2.983-3.438 ng/mL.

CSB-RA623829MA1HU

IHC image of CSB-RA623829MA1HU diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA623829MA1HU

IHC image of CSB-RA623829MA1HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA623829MA1HU

Immunofluorescence staining of SH-SY5Y cell with CSB-RA623829MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

CSB-RA623829MA1HU

The purity of ACVR2A&ACVR2B was greater than 95% as determined by SEC-HPLC

ACVR2A Antibodies

ACVR2A for Homo sapiens (Human)

ACVR2A Proteins

ACVR2A Proteins for Mus musculus (Mouse)

ACVR2A Proteins for Homo sapiens (Human)

ACVR2A Proteins for Rattus norvegicus (Rat)

ACVR2A Proteins for Xenopus laevis (African clawed frog)

ACVR2A Proteins for Ovis aries (Sheep)

ACVR2A Proteins for Bos taurus (Bovine)

ACVR2A Proteins for Gallus gallus (Chicken)