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CAP1

CAP1,全稱為 Adenylyl cyclase-associated protein 1,別名 CAP,是一種與細(xì)胞骨架動態(tài)調(diào)節(jié)相關(guān)的蛋白。研究發(fā)現(xiàn),CAP1 蛋白在多種生物的進(jìn)化過程中高度保守,提示其在細(xì)胞骨架調(diào)控中發(fā)揮著重要作用。CAP1 蛋白能夠結(jié)合游離的肌動蛋白單體,并加速肌動蛋白多聚化過程,從而影響細(xì)胞的遷移、增殖等生命活動。此外,CAP1 蛋白還與多種疾病的發(fā)生發(fā)展密切相關(guān),例如動脈粥樣硬化、肺癌等。近年來,CAP1 蛋白成為疾病診斷和治療研究的潛在靶點。研究表明,CAP1 蛋白的表達(dá)水平與動脈粥樣硬化嚴(yán)重程度呈正相關(guān),且在肺癌細(xì)胞中高表達(dá),可能參與肺癌細(xì)胞的遷移和增殖?;谶@些發(fā)現(xiàn),針對 CAP1 蛋白的藥物研發(fā)正在積極開展,例如開發(fā) CAP1 抑制劑等,以期用于相關(guān)疾病的治療。

熱銷產(chǎn)品

Recombinant Human Adenylyl cyclase-associated protein 1 (CAP1) (CSB-EP004486HUc7)

驗證數(shù)據(jù)

CSB-EP004486HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CAP1 Antibody (CSB-PA004486LA01HU)

驗證數(shù)據(jù)

CSB-PA004486LA01HU

Western Blot
Positive WB detected in: HepG2 whole cell lysate, Raji whole cell lysate, 293T whole cell lysate, K562 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate
All lanes: CAP1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

CSB-PA004486LA01HU

IHC image of CSB-PA004486LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA004486LA01HU

IHC image of CSB-PA004486LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA004486LA01HU

Immunofluorescence staining of U251 cells with CSB-PA004486LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Adenylyl cyclase-associated protein 1(CAP1) ELISA kit (CSB-EL004486HU)

驗證數(shù)據(jù)

CSB-EL004486HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL004486HU

規(guī)格:96T/48T

靈敏度:6.25 pg/mL

檢測范圍:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CAP1 Antibodies

CAP1 for Homo sapiens (Human)

CAP1 Proteins

CAP1 Proteins for Homo sapiens (Human)

CAP1 ELISA Kit

CAP1 ELISA Kit for Homo sapiens (Human)