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  4. Human Adenylyl cyclase-associated protein 1(CAP1) ELISA kit

Human Adenylyl cyclase-associated protein 1(CAP1) ELISA kit

  • 中文名稱：
    人腺苷酸環(huán)化酶關聯蛋白1(CAP1)酶聯免疫試劑盒
  • 貨號：
    CSB-EL004486HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人腺苷酸環(huán)化酶關聯蛋白1(CAP1)酶聯免疫試劑盒（CSB-EL004486HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CAP1含量。CAP1是一種與腺苷酸環(huán)化酶相關的蛋白，參與細胞骨架的調節(jié)和細胞遷移。其在mRNA穩(wěn)定性、翻譯和免疫識別中起關鍵作用，與動脈粥樣硬化、內皮細胞衰老等疾病相關。研究CAP1有助于揭示相關疾病的發(fā)病機制，為疾病治療提供新靶點。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，該產品可廣泛應用于基礎醫(yī)學研究領域，例如探究CAP1在代謝紊亂模型中的動態(tài)變化、評估炎癥相關信號通路的調控機制，或作為腫瘤微環(huán)境研究的輔助工具。實驗流程兼容常規(guī)酶標儀分析，為研究者提供穩(wěn)定可靠的定量數據支持，滿足細胞生物學、病理機制探索等科研場景的需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Adenylyl cyclase associated protein 1 ELISA Kit; Adenylyl cyclase-associated protein 1 ELISA Kit; CAP 1 ELISA Kit; CAP ELISA Kit; CAP; adenylate cyclase associated protein 1 (yeast) ELISA Kit; CAP1 ELISA Kit; CAP1 PEN ELISA Kit; CAP1-PEN ELISA Kit; CAP1_HUMAN ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CAP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %87-97
    1:2Average %94
    Range %90-98
    1:4Average %104
    Range %100-107
    1:8Average %95
    Range %92-99
  • 回收率：
    The recovery of human CAP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8884-93
    EDTA plasma (n=4)9288-96
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    16002.104 2.268 2.186 2.083
    8001.578 1.590 1.584 1.481
    4001.163 1.152 1.158 1.055
    2000.707 0.727 0.717 0.614
    1000.495 0.474 0.485 0.382
    500.292 0.278 0.285 0.182
    250.196 0.189 0.193 0.090
    00.102 0.104 0.103
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
  • 基因功能參考文獻：
    1. RETN and CAP1 polymorphisms and gene expression may be potential biomarkers for breast cancer risk PMID: 29641286
    2. Significant up-regulation of PBMCs CAP1, CD36 mRNA and plasma resistin found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin could be able to exert its effects stronger on cells with up-regulated CAP1 mRNA thus contributing atherosclerosis development. PMID: 28707728
    3. REVIEW: summarizes information available to date about the structural organization, regulation of functional activity of adenylyl cyclase-associated protein 1 (CAP1), and its participation in cellular processes PMID: 29534668
    4. Results identify a role for CAP1 in regulating proliferative transformation of cancer cells, with ERK signaling playing pivotal roles in mediating both cell functions. PMID: 27173014
    5. CAP1 expression is markedly increased in human glioma and that downregulation of CAP1 in tumors may serve as a treatment for glioma patients. PMID: 27432289
    6. our results indicated that CAP1 participated in the molecular pathological process of glioma PMID: 26810579
    7. a high expression of CAP1 is involved in the pathogenesis of EOC, and that the downregulation of CAP1 in tumor cells may be a therapeutic target for the treatment of patients with EOC. PMID: 25652936
    8. This study demonstrated an inverse relationship between CAP1 and MMP-9 expression, high expression of MMP-9 and low expression of CAP1 in those with chronic obstructive pulmonary disease compared with the non-chronic obstructive pulmonary disease group. PMID: 25332229
    9. CAP1 is involved in the brain metastasis in non-small cell lung cancer.CAP1 overexpression is associated with poor prognosis in non-small cell lung cancer patients. PMID: 25371324
    10. Overexpression of CAP1 in monocytes enhanced the resistin-induced increased activity of the cAMP-dependent signaling. PMID: 24606903
    11. results indicate that upregulated expression of CAP1 might contribute heavily to the metastasis of hepatocellular carcinoma. PMID: 24359721
    12. Overexpression of CAP1 is associated with breast carcinoma. PMID: 24522810
    13. CAP1 might be a potential molecular targeted therapy for surgery and immune treatment. PMID: 24509166
    14. overexpression of CAP1 in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer. PMID: 23842884
    15. CAP1 depletion also led to changes in cofilin phosphorylation and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading. PMID: 23737525
    16. Findings suggest that CAP1 (cyclase-associated protein 1) is involved in the metastasis of esophageal squamous cell carcinoma, and increased expression may indicate a poor prognosis. PMID: 23904342
    17. plays a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin and through its effect on both ends of actin filament PMID: 11950878
    18. Based on an analysis of 1075 beta-thalassemia alleles the CAP+1 (A-->C) mutation constituted 3.2% of north Indians. PMID: 17900295
    19. The high turnover rate of CAP1 by MMP-9, comparable to that of gelatin as the natural extracellular substrate of this enzyme, may be critical to prevent pathological conditions associated with considerable cytolysis. PMID: 18671965
    20. These studies suggest that CAP1 provides a direct link from the actin cytoskeleton to the mitochondria by functioning as an actin shuttle. PMID: 18716285
    21. The overexpression of CAP1 in pancreatic cancers is demonstrated and the involvement of CAP1 in the aggressive behavior of pancreatic cancer cells is suggested. PMID: 19188911

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    CAP family
  • 數據庫鏈接：

    HGNC: 20040

    OMIM: 617801

    KEGG: hsa:10487

    STRING: 9606.ENSP00000361878

    UniGene: Hs.370581