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CCL21

CCL21,即C-C基序趨化因子配體21,別名ECL、SLC、CKb9、TCA4、SCYA21。CCL21是一種小分子細(xì)胞因子,屬于CC亞家族的趨化因子,主要在淋巴管起始處和淋巴器官中組成型表達(dá),存在于幾種基質(zhì)細(xì)胞和高內(nèi)皮小靜脈(HEV)上,可以與糖胺聚糖(GAG)結(jié)合并固定在內(nèi)皮細(xì)胞表面。CCL21通過與趨化因子受體CCR7和CXCR3結(jié)合,發(fā)揮其生物學(xué)功能。CCL21對胸腺細(xì)胞和活化的T細(xì)胞具有體外趨化作用,但對B細(xì)胞、巨噬細(xì)胞或中性粒細(xì)胞沒有趨化作用。CCL21也是一種有效的T細(xì)胞遷移和粘附刺激物,可以促進(jìn)T細(xì)胞向次級淋巴器官的遷移,對淋巴細(xì)胞歸巢至二級淋巴器官中發(fā)揮作用,具有重要的免疫調(diào)節(jié)作用。

熱銷產(chǎn)品

Recombinant Human C-C motif chemokine 21 (CCL21) (CSB-EP004785HUc0)

驗(yàn)證數(shù)據(jù)

CSB-EP004785HUc0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCL21 Antibody (CSB-PA576836)

驗(yàn)證數(shù)據(jù)

CSB-PA576836

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA576836(CCL21 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA576836

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA576836(CCL21 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

CCL21 Antibodies

CCL21 for Homo sapiens (Human)

CCL21 Proteins

CCL21 Proteins for Homo sapiens (Human)

CCL21 Proteins for Macaca mulatta (Rhesus macaque)

CCL21 ELISA Kit

CCL21 ELISA Kit for Homo sapiens (Human)