CCL24
CCL24蛋白全稱(chēng)為C-C基序趨化因子配體24，又名MPIF-2或嗜酸性粒細(xì)胞趨化因子-2，屬于調(diào)控免疫細(xì)胞遷移的關(guān)鍵蛋白。該蛋白通過(guò)與細(xì)胞表面的特異性受體結(jié)合，引導(dǎo)嗜酸性粒細(xì)胞、單核細(xì)胞等免疫細(xì)胞向炎癥部位聚集，在過(guò)敏反應(yīng)和組織修復(fù)中發(fā)揮雙重作用。CCL24異常表達(dá)與哮喘、特應(yīng)性皮炎等過(guò)敏性疾病密切相關(guān)，在特發(fā)性肺纖維化患者肺泡灌洗液中也可檢測(cè)到濃度升高。近年來(lái)，針對(duì)CCL24的抗體藥物研發(fā)取得突破，已有單克隆抗體完成Ⅱ期臨床試驗(yàn)，證實(shí)可顯著降低慢性蕁麻疹患者復(fù)發(fā)率。與此同時(shí)，小分子抑制劑的設(shè)計(jì)聚焦于阻斷其與受體相互作用，部分候選化合物在動(dòng)物模型中展現(xiàn)出抑制肺部纖維化的潛力。隨著對(duì)炎癥微環(huán)境研究的深入，該蛋白在腫瘤免疫逃逸中的作用也逐漸被揭示，為癌癥聯(lián)合治療提供了新方向。
熱銷(xiāo)產(chǎn)品
Recombinant Human C-C motif chemokine 24 (CCL24) (CSB-EP004788HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCL24 Antibody (CSB-PA05909A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA05909A0Rb at dilution of 1:100
CCL24 Antibodies
CCL24 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA05909A0Rb | CCL24 Antibody | Human | ELISA, IHC |
| CSB-PA272302 | CCL24 Antibody | Human | ELISA,WB |
CCL24 Proteins
CCL24 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP004788HU CSB-BP004788HU CSB-MP004788HU CSB-EP004788HU-B |
Recombinant Human C-C motif chemokine 24 (CCL24) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004788HU | Recombinant Human C-C motif chemokine 24 (CCL24) | E.coli |
| CSB-RP059094h | Recombinant Human C-C motif chemokine 24 (CCL24) | E.coli |
| CSB-AP000971HU | Recombinant Human C-C motif chemokine 24 protein (CCL24), partial (Active) | E.Coli |
CCL24 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP737958DO CSB-EP737958DO CSB-BP737958DO CSB-MP737958DO CSB-EP737958DO-B |
Recombinant Dog C-C motif chemokine 24 (CCL24) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL24 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP872867MO CSB-EP872867MO CSB-BP872867MO CSB-MP872867MO CSB-EP872867MO-B |
Recombinant Mouse C-C motif chemokine 24 (Ccl24) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001361MO | Recombinant Mouse C-C motif chemokine 24 protein (Ccl24) | E.Coli |
CCL24 ELISA Kit
CCL24 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E10360h | Human Eotaxin 2/CCL24 ELISA Kit | serum, plasma, tissue homogenates | 67.660 pg/mL |
CCL24 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E07278m | Mouse Eotaxin 2 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/ml |
