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CCL5

CCL5全稱為C-C基序趨化因子配體5，又稱RANTES（調(diào)節(jié)激活正常T細(xì)胞表達(dá)和分泌因子），是免疫系統(tǒng)重要的信號分子。CCL5主要由T淋巴細(xì)胞、血小板和某些上皮細(xì)胞分泌，能夠招募單核細(xì)胞、嗜酸性粒細(xì)胞等免疫細(xì)胞向炎癥部位聚集。通過與細(xì)胞表面CCR1、CCR3和CCR5等受體結(jié)合，不僅參與抗病毒免疫反應(yīng)，還與HIV病毒利用CCR5共受體入侵細(xì)胞的過程密切相關(guān)。在病理狀態(tài)下，CCL5過度表達(dá)與類風(fēng)濕性關(guān)節(jié)炎、動脈粥樣硬化等慢性炎癥疾病相關(guān)，同時被發(fā)現(xiàn)能通過調(diào)控腫瘤微環(huán)境促進(jìn)乳腺癌、肺癌等惡性腫瘤的轉(zhuǎn)移。
近年針對CCL5及其受體的藥物開發(fā)取得進(jìn)展，抗HIV藥物馬拉維諾正是通過阻斷CCR5受體發(fā)揮作用。在癌癥治療領(lǐng)域，多個臨床前研究證實抑制CCL5可降低腫瘤侵襲性，相關(guān)單克隆抗體藥物已進(jìn)入Ⅰ期臨床試驗。由于CCL5在抗感染與促腫瘤中存在雙重作用，其靶向治療需精準(zhǔn)調(diào)控表達(dá)水平，目前科研團(tuán)隊正探索基于納米載體的局部遞送系統(tǒng)以平衡療效與安全性。

熱銷產(chǎn)品

Recombinant Human C-C motif chemokine 5 (CCL5) (CSB-EP004800HUc7)

驗證數(shù)據(jù)

CSB-EP004800HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCL5 Antibody (CSB-PA05955A0Rb)

驗證數(shù)據(jù)

CSB-PA05955A0Rb

Western blot
All lanes: CCL5 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 10 kDa
Observed band size: 70 kDa

CCL5 Antibodies

CCL5 for Homo sapiens (Human)

產(chǎn)品貨號 產(chǎn)品名稱 種屬反應(yīng)性 應(yīng)用類型
CSB-PA05955A0Rb CCL5 Antibody Human ELISA, WB
CSB-PA05955B0Rb CCL5 Antibody, HRP conjugated Human ELISA
CSB-PA05959A0Rb CCL5 Antibody Human ELISA, WB
CSB-PA040300 CCL5 Antibody Human,Mouse,Rat IHC, ELISA

CCL5 Proteins

CCL5 Proteins for Cavia porcellus (Guinea pig)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP004800GU
CSB-EP004800GU
CSB-BP004800GU
CSB-MP004800GU
CSB-EP004800GU-B
 Recombinant Guinea pig C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Homo sapiens (Human)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP004800HU
CSB-BP004800HU
CSB-MP004800HU
CSB-EP004800HU-B
 Recombinant Human C-C motif chemokine 5 (CCL5) Yeast
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli
CSB-EP004800HUe0 Recombinant Human C-C motif chemokine 5 (CCL5) E.coli
CSB-EP004800HU Recombinant Human C-C motif chemokine 5 (CCL5) E.coli
CSB-AP000871HU Recombinant Human C-C motif chemokine 5 protein (CCL5) E.Coli
CSB-EP004800HUc7 Recombinant Human C-C motif chemokine 5 (CCL5) E.coli
CSB-EP004800HUg5 Recombinant Human C-C motif chemokine 5 (CCL5) E.coli
CSB-EP004800HUd7 Recombinant Human C-C motif chemokine 5 (CCL5) E.coli

CCL5 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP004800MO
CSB-EP004800MO
CSB-BP004800MO
CSB-MP004800MO
CSB-EP004800MO-B
 Recombinant Mouse C-C motif chemokine 5 (Ccl5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli
CSB-AP001241MO Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) E.Coli

CCL5 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP004800RA
CSB-EP004800RA
CSB-BP004800RA
CSB-MP004800RA
CSB-EP004800RA-B
 Recombinant Rat C-C motif chemokine 5 (Ccl5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP004800BO
CSB-EP004800BO
CSB-BP004800BO
CSB-MP004800BO
CSB-EP004800BO-B
 Recombinant Bovine C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP643672PI
CSB-EP643672PI
CSB-BP643672PI
CSB-MP643672PI
CSB-EP643672PI-B
 Recombinant Pig C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP808495DO
CSB-EP808495DO
CSB-BP808495DO
CSB-MP808495DO
CSB-EP808495DO-B
 Recombinant Dog C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP814163MOW
CSB-EP814163MOW
CSB-BP814163MOW
CSB-MP814163MOW
CSB-EP814163MOW-B
 Recombinant Macaca mulatta C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Sigmodon hispidus (Hispid cotton rat)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP842062SZK
CSB-EP842062SZK
CSB-BP842062SZK
CSB-MP842062SZK
CSB-EP842062SZK-B
 Recombinant Sigmodon hispidus C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Felis catus (Cat) (Felis silvestris catus)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP844627CA
CSB-EP844627CA
CSB-BP844627CA
CSB-MP844627CA
CSB-EP844627CA-B
 Recombinant Cat C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 Proteins for Equus caballus (Horse)

產(chǎn)品貨號 產(chǎn)品名稱 來源
CSB-YP847581HO
CSB-EP847581HO
CSB-BP847581HO
CSB-MP847581HO
CSB-EP847581HO-B
 Recombinant Horse C-C motif chemokine 5 (CCL5) Yeast
E.coli
Baculovirus
Mammalian cell
In Vivo Biotinylation in E.coli

CCL5 ELISA Kit

CCL5 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

產(chǎn)品貨號 產(chǎn)品名稱 樣本類型 靈敏度
CSB-EL004800DO Dog C-C motif chemokine 5(CCL5) ELISA kit serum, plasma, tissue homogenates 0.081 ng/mL

CCL5 ELISA Kit for Homo sapiens (Human)

產(chǎn)品貨號 產(chǎn)品名稱 樣本類型 靈敏度
CSB-E17375h Human C-C motif chemokine 5 (CCL5/D17S136E/SCYA5) ELISA kit serum, plasma, cell culture supernates, tissue homogenates 2.307 pg/mL

CCL5 ELISA Kit for Mus musculus (Mouse)

產(chǎn)品貨號 產(chǎn)品名稱 樣本類型 靈敏度
CSB-E09256m Mouse regulated on activation in normal T-cell expressed and secreted,RANTES ELISA kit serum, plasma, tissue homogenates 0.039 ng/mL

CCL5 ELISA Kit for Rattus norvegicus (Rat)

產(chǎn)品貨號 產(chǎn)品名稱 樣本類型 靈敏度
CSB-E07398r Rat regulated on activation in normal T-cell expressed and secreted/C-C motif chemokine 5 (RANTES/CCL5) ELISA kit serum, plasma, cell culture supernates, tissue homogenates 0.039 ng/mL