CD79B
CD79B,即B細(xì)胞受體信號(hào)轉(zhuǎn)導(dǎo)亞單位β,別名包括Igβ、B29、CD79b等。它是一種B細(xì)胞受體(BCR)的組成部分,由CD79B基因編碼,主要在B細(xì)胞表面表達(dá)。CD79B與CD79A(Igα)形成異源二聚體,參與BCR介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)過程,對(duì)B細(xì)胞的活化、增殖和分化具有重要作用 。CD79B的作用機(jī)制主要是通過與BCR復(fù)合物中的mIgM或mIgD結(jié)合,轉(zhuǎn)導(dǎo)抗原識(shí)別后的信號(hào)。當(dāng)BCR識(shí)別并結(jié)合抗原后,CD79B能夠激活Src家族激酶,如Lyn,進(jìn)而激活下游的Syk和Btk等酪氨酸激酶,觸發(fā)信號(hào)級(jí)聯(lián)反應(yīng)。這些信號(hào)通路包括MAPK、PI3K/Akt等,最終導(dǎo)致細(xì)胞內(nèi)鈣離子的釋放、細(xì)胞增殖和分化等生物學(xué)效應(yīng) 。在生物學(xué)意義上,CD79B在B細(xì)胞發(fā)育、成熟和功能中發(fā)揮關(guān)鍵作用。它不僅參與B細(xì)胞受體介導(dǎo)的信號(hào)傳導(dǎo),還可能參與調(diào)節(jié)B細(xì)胞的存活和凋亡。此外,CD79B在多種B細(xì)胞來源的惡性腫瘤中高度表達(dá),如彌漫性大B細(xì)胞淋巴瘤(DLBCL),使其成為治療某些B細(xì)胞惡性腫瘤的潛在靶點(diǎn)。已有針對(duì)CD79B的抗體偶聯(lián)藥物(ADC),如Polatuzumab vedotin,被開發(fā)用于治療某些類型的非霍奇金淋巴瘤(NHL) 。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD79B at 2 μg/ml can bind Anti-CD79B recombinant antibody(CSB-RA004958MA2HU). The EC50 is 3.214-3.642 ng/mL.
CD79B Antibody (CSB-PA004958LA01HU)
驗(yàn)證數(shù)據(jù)

Immunofluorescent analysis of MCF-7 cells using CSB-PA004958LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CD79B Antibodies
CD79B for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA005233 | CD79B Antibody | Human | WB, IHC, ELISA |
CSB-PA004958LA01HU | CD79B Antibody | Human | ELISA, IF |
CSB-PA004958LB01HU | CD79B Antibody, HRP conjugated | Human | ELISA |
CSB-RA004958MA2HU | CD79B Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD79B Proteins
CD79B Proteins for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP004958MO1 CSB-EP004958MO1 CSB-BP004958MO1 CSB-MP004958MO1 CSB-EP004958MO1-B |
Recombinant Mouse B-cell antigen receptor complex-associated protein beta chain (Cd79b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004958MO | Recombinant Mouse B-cell antigen receptor complex-associated protein beta chain (Cd79b) | in vitro E.coli expression system |
CD79B Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP004958HU1 CSB-EP004958HU1 CSB-BP004958HU1 CSB-EP004958HU1-B |
Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF004958HU | Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B) | in vitro E.coli expression system |
CSB-MP004958HU1 | Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),partial (Active) | Mammalian cell |
CSB-MP004958HU1p7 | Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B),Partial (Active) | Mammalian cell |