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  4. CD79B Recombinant Monoclonal Antibody

CD79B Recombinant Monoclonal Antibody

  • 中文名稱：
    CD79B Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA004958MA2HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CD79B with Anti-CD79B recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004958HU1) at 2 μg/mL can bind Anti-CD79B recombinant antibody. The EC50 is 3.214-3.642 ng/mL.
    • The Binding Activity of Human CD79A&CD79B with Anti-CD79B recombinant antibody
      Activity:Measured by its binding ability in a functional ELISA. Immobilized Human CD79A&CD79B(CSB-MP5861HU) at 2 μg/mL can bind Anti-CD79B recombinant antibody. The EC50 is 14.85-17.47 ng/mL.
    • The Binding Activity of Human CD79B with Anti-CD79B recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79B(CSB-MP004958HU1p7) at 2 μg/mL can bind Anti-CD79B recombinant antibody. The EC50 is 31.97-35.69 ng/mL.
    • Untransfected HEK-293T cells (green line) and transfected Human CD79B HEK-293T stable cells (red line) were stained with anti-CD79B antibody(CSB-RA004958MA2HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
    • Untransfected HEK-293T cells (green line) and transfected Human CD79A&CD79B HEK-293T stable cells (red line) were stained with anti-CD79B antibody(CSB-RA004958MA2HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD79B重組單克隆抗體（產(chǎn)品編號：CSB-RA004958MA2HU）是針對B細胞受體復(fù)合物關(guān)鍵組分CD79B蛋白開發(fā)的高特異性科研工具。該抗體靶向的CD79B分子與CD79A共同構(gòu)成B細胞抗原受體（BCR）的信號轉(zhuǎn)導(dǎo)模塊，在B細胞活化、增殖及免疫應(yīng)答調(diào)控中發(fā)揮核心作用，其表達異常與B細胞淋巴瘤等疾病密切相關(guān)。本產(chǎn)品經(jīng)嚴格驗證可應(yīng)用于ELISA檢測，推薦工作稀釋范圍為1:5000至1:50000，在優(yōu)化條件下展現(xiàn)出優(yōu)異的檢測靈敏度和抗原結(jié)合特異性，能夠準確識別天然及重組表達的CD79B蛋白。適用于B細胞功能研究、BCR信號通路解析、免疫微環(huán)境分析及B細胞相關(guān)疾病機制探索等科研場景，例如在淋巴瘤模型構(gòu)建或自身免疫性疾病研究中檢測CD79B的表達動態(tài)。通過重組抗體技術(shù)保證批次間一致性，為實驗提供穩(wěn)定可靠的數(shù)據(jù)支持，滿足分子互作、蛋白定量等基礎(chǔ)研究需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    AGM6 antibody; B cell antigen receptor complex associated protein beta chain antibody; B cell specific glycoprotein B29 antibody; B-cell antigen receptor complex-associated protein beta chain antibody; B-cell-specific glycoprotein B29 antibody; B29 antibody; B29/Ig-beta/CD79b antibody; CD 79b antibody; CD79b antibody; CD79b antigen (immunoglobulin associated beta) antibody; CD79b antigen antibody; CD79b molecule antibody; CD79b molecule immunoglobulin associated beta antibody; CD79b protein antibody; CD79B_HUMAN antibody; Ig beta antibody; Ig-beta antibody; IGB antibody; Igbeta antibody; Immunoglobulin associated B29 antibody; Immunoglobulin associated B29 protein antibody; Immunoglobulin associated beta antibody; Immunoglobulin associated protein antibody; Immunoglobulin-associated B29 protein antibody; MGC108607 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD79B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8E9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • 基因功能參考文獻：
    1. CD79B mutations were found in six of 19 cases (31.6%) of primary CNS diffuse large B-cell lymphoma , all in the Y196 mutation hotspot PMID: 28856744
    2. Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of CD79B mutations. PMID: 28803429
    3. hotspot mutations of CD79B Y196 and MYD88 L265 may serve as a genetic hallmark for primary central nervous system lymphoma PMID: 26111727
    4. CD79B overexpression leading to activation of AKT/MAPK is a potential mechanism underlying primary ibrutinib resistance in ABC-DLBCL, and support its utility as an effective biomarker to predict therapeutic response to ibrutinib. PMID: 26699656
    5. Novel CD79B variations in mature B-cell non-Hodgkin's lymphoma patients were detected. PMID: 27010137
    6. MYD88 L265P and CD79B mutations were frequently detected in primary breast diffuse large B-cell lymphoma. PMID: 26752547
    7. Oncogenic CD79B mutation is associated with primary diffuse large B-cell lymphomas of central nervous system. PMID: 25347427
    8. Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations. PMID: 25501023
    9. Abberant expression of CD79b in non-B cells caused unwanted reactivity, rendering CD79b unsuitable for T-cell receptor - based immunotherapies. PMID: 25414443
    10. results suggest that MYD88 mutations, and to a lesser extent CD79B mutations, are important drivers of lymphomagenesis in PTL PMID: 24253023
    11. CD79B and MYD88 mutations are associated with an older age at onset in diffuse large b-cell lymphoma with a significant overlap, which did not affect the outcome of the disease. PMID: 24444466
    12. CD79B point mutation is associated with B-cell non-Hodgkin lymphomas. PMID: 23361872
    13. Data indicate a secondary promoter located within exon 2 maintained full levels and specificity of hCD79b transcription. PMID: 23649625
    14. The present study failed to find any mut-ation in MYD88, CARD11 or CD79B in ocular MALT lymphoma. PMID: 22808296
    15. Expression of CD79b is downregulated in both plasma cells and plasma cell myeloma. PMID: 21355953
    16. The B cell-specific B29 gene promoter is transactivated in B and non-B cells by cotransfection with the B cell-specific octamer cofactor gene, Bob1 (OCA-B/OBF-1). PMID: 11907094
    17. The alternative splicing variant DeltaCD79b may be a powerful modulator of BCR signaling that may play an important role in normal and malignant B cell PMID: 12384401
    18. Following B cell receptor cross-linking, a significant amount of the transgenic Ig beta pool (together with Ig alpha) remains on the B cell surface independent of surface immunoglobulin internalization. PMID: 15661909
    19. Results reveal tissue-specific patterns of chromatin structures and transcriptional controls at the CD79b/GH locus in B cells distinct from those in the pituitary gland and placenta. PMID: 16847312
    20. establish a strong linkage between Igbeta mRNA expression and somatic hypermutation in chronic lymphocytic leukaemia and highlight the complex relationships between biochemical parameters and clinical status in this disease PMID: 17315213
    21. Ig-beta was phosphorylated in about 20% of myeloma IgG BCR isolates, but not in normal B-cell controls. PMID: 17701175
    22. These results indicate that mutations in Igbeta can cause agammaglobulinemia in man. PMID: 17709424
    23. mutations responsible for agammaglobulinemia in humans PMID: 18978465

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  • 相關(guān)疾?。?/div>
    Agammaglobulinemia 6, autosomal recessive (AGM6)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    B-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1699

    OMIM: 147245

    KEGG: hsa:974

    STRING: 9606.ENSP00000376544

    UniGene: Hs.89575