CFD
補(bǔ)體因子D（Complement Factor D，CFD）又稱脂肪細(xì)胞特異性分泌因子Adipsin，是補(bǔ)體系統(tǒng)旁路途徑的核心蛋白酶。CFD由脂肪細(xì)胞及肝臟合成，在血液中以低濃度持續(xù)存在，通過特異性切割補(bǔ)體因子B激活補(bǔ)體級(jí)聯(lián)反應(yīng)，形成C3轉(zhuǎn)化酶放大炎癥信號(hào)。CFD異常表達(dá)與年齡相關(guān)性黃斑變性密切相關(guān)，其過度激活會(huì)導(dǎo)致視網(wǎng)膜色素上皮細(xì)胞損傷，全球約15%的AMD患者存在CFD基因變異。在代謝性疾病領(lǐng)域，CFD水平升高可加劇胰島素抵抗，與2型糖尿病腎病進(jìn)展呈正相關(guān)。目前針對(duì)CFD的單克隆抗體藥物APL-2已完成二期臨床試驗(yàn)，通過抑制補(bǔ)體旁路途徑顯著降低地理萎縮患者的病灶擴(kuò)大速度。CFD抑制劑還被探索用于陣發(fā)性睡眠性血紅蛋白尿癥和IgA腎病的治療，已有小分子化合物進(jìn)入臨床前研究階段。
熱銷產(chǎn)品
CFD Antibody (CSB-PA005271ESR2HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005271ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005271ESR2HU at dilution of 1:100
CFD Antibodies
CFD for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005271ESR2HU | CFD Antibody | Human | ELISA, IHC |
CFD Proteins
CFD Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005271RA | Recombinant Rat Complement factor D (Cfd) | Yeast |
| CSB-EP005271RA | Recombinant Rat Complement factor D (Cfd) | E.coli |
| CSB-BP005271RA CSB-EP005271RA-B |
Recombinant Rat Complement factor D (Cfd) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP005271RA | Recombinant Rat Complement factor D (Cfd) | Mammalian cell |
| CSB-MP005271RAd9 | Recombinant Rat Complement factor D (Cfd) | Mammalian cell |
CFD Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005271PI CSB-EP005271PI CSB-BP005271PI CSB-MP005271PI CSB-EP005271PI-B |
Recombinant Pig Complement factor D (CFD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005271HU CSB-EP005271HU CSB-BP005271HU CSB-MP005271HU CSB-EP005271HU-B |
Recombinant Human Complement factor D (CFD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005271MO CSB-EP005271MO CSB-BP005271MO CSB-MP005271MO CSB-EP005271MO-B |
Recombinant Mouse Complement factor D (Cfd) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP660982BO CSB-EP660982BO CSB-BP660982BO CSB-MP660982BO CSB-EP660982BO-B |
Recombinant Bovine Complement factor D (CFD) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CFD ELISA Kit
CFD ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14369h | Human Adipsin ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
