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CHRNB2

神經(jīng)元煙堿型乙酰膽堿受體β2亞基(CHRNB2)是神經(jīng)系統(tǒng)重要的膜蛋白組分,常被稱為nAChR β2亞基。這類蛋白質(zhì)廣泛分布于大腦皮層、丘腦等區(qū)域,通過與乙酰膽堿結(jié)合形成離子通道,調(diào)控神經(jīng)遞質(zhì)的釋放與神經(jīng)元興奮性。CHRNB2參與維持覺醒狀態(tài)、認知功能及痛覺感知,其功能異??赡芤l(fā)癲癇、阿爾茨海默病及尼古丁成癮。某些家族性癲癇病例中已發(fā)現(xiàn)該亞基基因突變會導(dǎo)致神經(jīng)元過度興奮。
近年來針對β2亞基的藥物開發(fā)聚焦于神經(jīng)系統(tǒng)疾病領(lǐng)域。例如伐尼克蘭作為α4β2受體部分激動劑,已用于戒煙治療并顯示出調(diào)節(jié)多巴胺釋放的潛力。在抗癲癇藥物篩選中,特定小分子化合物通過增強β2亞基介導(dǎo)的電流展現(xiàn)出調(diào)控神經(jīng)元網(wǎng)絡(luò)同步性的作用。此外,該亞基與β淀粉樣蛋白的相互作用機制正成為阿爾茨海默病研究的新方向,相關(guān)抗體藥物已進入臨床前評估階段。

熱銷產(chǎn)品

Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2), partial (CSB-EP005396HU1)

驗證數(shù)據(jù)

CSB-EP005396HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CHRNB2 Antibody (CSB-PA005396LA01HU)

驗證數(shù)據(jù)

CSB-PA005396LA01HU

Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: CHRNB2 antibody at 6.05μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa

CSB-PA005396LA01HU

Immunofluorescence staining of SH-SY5Y cells with CSB-PA005396LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA005396LA01HU

IHC image of CSB-PA005396LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CHRNB2 Antibodies

CHRNB2 for Homo sapiens (Human)

CHRNB2 Proteins

CHRNB2 Proteins for Homo sapiens (Human)