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CLDN18

CLDN18,即緊密連接蛋白18,別名Claudin-18。CLDN18由人類CLDN18基因編碼,該基因位于3號(hào)染色體的3q28區(qū)域。CLDN18是一種緊密連接蛋白,主要參與形成細(xì)胞間的緊密連接,調(diào)節(jié)細(xì)胞旁路的通透性和維持上皮細(xì)胞層的完整性。其作用機(jī)制涉及與細(xì)胞膜上的其他緊密連接蛋白相互作用,形成穩(wěn)定的緊密連接結(jié)構(gòu),控制分子和離子在細(xì)胞間的流動(dòng)。CLDN18在肺泡上皮細(xì)胞和胃上皮細(xì)胞中高度表達(dá),對(duì)于肺和胃的發(fā)育和功能至關(guān)重要。CLDN18的異常表達(dá)與多種疾病相關(guān),包括肺癌和胃癌。特別是在肺癌中,CLDN18的表達(dá)與腫瘤的侵襲性和預(yù)后不良相關(guān),是潛在的診斷標(biāo)志物和治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Macaca fascicularis Claudin 18.2 (CLDN18.2)-VLPs (Active) (CSB-MP4304MOV)

驗(yàn)證數(shù)據(jù)

CSB-MP4304MOV

CSB-MP4304MOV is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP4304MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CLDN18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant Antibody (CSB-RA005498A1HU), the EC50 is 2.806-3.641 ng/ml.

CSB-MP4304MOV

The purity of VLPs was greater than 90% as determined by SEC-HPLC

Recombinant Mouse Claudin-18.2 (Cldn18.2)-VLPs (Active) (CSB-MP005498MO(F3))

驗(yàn)證數(shù)據(jù)

CSB-MP005498MO(F3)

CSB-MP005498MO(F3) is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP005498MO(F3)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Cldn18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005498A1HU), the EC50 is 6.115-11.01 ng/mL.

Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs (Active) (CSB-MP005498HU(A5))

驗(yàn)證數(shù)據(jù)

CSB-MP005498HU(A5)

Western Blot
CSB-MP005498HU(A5) is detected by Mouse anti-6*His monoclonal antibody.The three bands respectively correspond to monomer, Homodimer, Homotrimer

CSB-MP005498HU(A5)

Activity
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.

CSB-MP005498HU(A5)

The presence of VLP-like structures was confirmed by TEM

CSB-MP005498HU(A5)

Western Blot
CSB-MP005498HU(A5) is detected by Anti-Claudin 18 Antibody.The two bands respectively correspond to monomer, Homodimer

CLDN18 Recombinant Monoclonal Antibody (CSB-RA005498A2HU)

驗(yàn)證數(shù)據(jù)

CSB-RA005498A2HU

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA005498A2HU

The Binding Activity of Human CLDN18.2 with Anti-CLDN18 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/mL can bind Anti-CLDN18 recombinant antibody, the EC50 is 2.947-8.782 ng/mL.

CLDN18 Antibodies

CLDN18 for Homo sapiens (Human)

CLDN18 Proteins

CLDN18 Proteins for Mus musculus (Mouse)

CLDN18 Proteins for Homo sapiens (Human)

CLDN18 Proteins for Bos taurus (Bovine)