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CLPTM1L

CLPTM1L,全稱(chēng) Cleft Lip and Palate Transmembrane Protein 1-Like,常見(jiàn)別名包括 CRR9p 和 CLPTM1-like 蛋白。該蛋白主要表達(dá)于皮膚、肺和胰腺等組織中,定位于高爾基體和內(nèi)質(zhì)網(wǎng),參與細(xì)胞內(nèi)的囊泡運(yùn)輸和蛋白質(zhì)分選過(guò)程。研究表明,CLPTM1L 蛋白可能通過(guò)抑制細(xì)胞凋亡促進(jìn)細(xì)胞存活,并與端粒酶活性調(diào)節(jié)相關(guān),影響細(xì)胞衰老和增殖。該蛋白的異常表達(dá)或突變與多種癌癥風(fēng)險(xiǎn)增加有關(guān),特別是肺癌、胰腺癌和卵巢癌。例如,在非小細(xì)胞肺癌中,CLPTM1L 蛋白的高表達(dá)與較差的預(yù)后相關(guān)。因此,CLPTM1L 蛋白已成為潛在的診斷標(biāo)志物和治療靶點(diǎn)。目前,針對(duì) CLPTM1L 蛋白的藥物研發(fā)尚處于探索階段,但已有研究表明,抑制 CLPTM1L 蛋白可以抑制腫瘤發(fā)生,而提高其表達(dá)則可能增加細(xì)胞對(duì)凋亡信號(hào)的敏感性。

熱銷(xiāo)產(chǎn)品

CLPTM1L Antibody (CSB-PA850323LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA850323LA01HU

Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: CLPTM1L antibody at 3.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63, 59 kDa
Observed band size: 63 kDa

CSB-PA850323LA01HU

IHC image of CSB-PA850323LA01HU diluted at 1:800 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA850323LA01HU

IHC image of CSB-PA850323LA01HU diluted at 1:800 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA850323LA01HU

Immunofluorescence staining of A549 cells with CSB-PA850323LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CLPTM1L Antibodies

CLPTM1L for Homo sapiens (Human)

CLPTM1L Proteins

CLPTM1L Proteins for Homo sapiens (Human)