CXCL13
CXCL13的全稱為C-X-C基序趨化因子13，也被稱為B淋巴細(xì)胞趨化因子（BLC）或BCA-1。該蛋白在免疫系統(tǒng)中扮演重要角色，能夠特異性引導(dǎo)B細(xì)胞和濾泡輔助T細(xì)胞向淋巴組織中的特定區(qū)域遷移，例如促進(jìn)生發(fā)中心的形成，從而增強(qiáng)抗體產(chǎn)生和長期免疫記憶。CXCL13的異常表達(dá)與多種疾病密切相關(guān)，例如類風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡等自身免疫疾病中常出現(xiàn)其水平升高，而在某些B細(xì)胞淋巴瘤中，CXCL13可能通過持續(xù)激活微環(huán)境促進(jìn)腫瘤發(fā)展。此外，中樞神經(jīng)系統(tǒng)感染萊姆病時，腦脊液中CXCL13濃度顯著上升，已成為輔助診斷的重要生物標(biāo)志物。
近年來針對CXCL13的藥物研發(fā)主要聚焦于阻斷其與受體CXCR5的結(jié)合。單克隆抗體類藥物已進(jìn)入早期臨床研究階段，擬用于治療自身免疫性疾病及部分實(shí)體瘤。另有小分子抑制劑通過干擾CXCL13介導(dǎo)的細(xì)胞遷移途徑，在動物模型中顯示出抑制炎癥和腫瘤轉(zhuǎn)移的效果。這些進(jìn)展為相關(guān)疾病的精準(zhǔn)治療提供了新方向。
熱銷產(chǎn)品
Recombinant Human C-X-C motif chemokine 13 (CXCL13) (CSB-EP006243HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCL13 Antibody (CSB-PA06139A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06139A0Rb at dilution of 1:100
Human B-Lymphocyte Chemoattractant 1,BLC-1 ELISA Kit (CSB-E10019h)
驗(yàn)證數(shù)據(jù)
貨號：CSB-E10019h
規(guī)格：96T/48T
靈敏度：19.5 pg/mL
檢測范圍：78 pg/mL-5000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CXCL13 Antibodies
CXCL13 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006243GA01HU | CXCL13 Antibody | Human | ELISA,WB |
| CSB-PA005137 | CXCL13 Antibody | Human | WB, ELISA |
| CSB-PA06139A0Rb | CXCL13 Antibody | Human | ELISA, IHC |
CXCL13 Proteins
CXCL13 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006243HU CSB-BP006243HU CSB-MP006243HU CSB-EP006243HU-B |
Recombinant Human C-X-C motif chemokine 13 (CXCL13) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006243HU1 | Recombinant Human C-X-C motif chemokine 13 protein (CXCL13), partial | E.coli |
| CSB-AP000771HU | Recombinant Human C-X-C motif chemokine 13 protein (CXCL13) | E.Coli |
| CSB-EP006243HU | Recombinant Human C-X-C motif chemokine 13 (CXCL13) | E.coli |
CXCL13 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006243MO CSB-EP006243MO CSB-BP006243MO CSB-MP006243MO CSB-EP006243MO-B |
Recombinant Mouse C-X-C motif chemokine 13 (Cxcl13) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL13 ELISA Kit
CXCL13 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10019h | Human B-Lymphocyte Chemoattractant 1,BLC-1 ELISA Kit | serum, plasma, tissue homogenates | 19.5 pg/mL |
CXCL13 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16832m | Mouse C-X-C motif chemokine 13 (Cxcl13/Blc/Scyb13) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates | 0.096 ng/mL |
