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Mouse C-X-C motif chemokine 13 (Cxcl13/Blc/Scyb13) ELISA kit

  • 中文名稱:
    小鼠CXC趨化因子13(Cxcl13/Blc/Scyb13)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-E16832m
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠CXC趨化因子13(Cxcl13/Blc/Scyb13)酶聯(lián)免疫試劑盒(CSB-E16832m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、組織培養(yǎng)上清液樣本中的CXCL13含量。CXCL13,又稱BCA-1或BLC,是一種穩(wěn)態(tài)趨化因子,由次級淋巴組織的基質細胞分泌,主要吸引B淋巴細胞。CXCL13通過其受體CXCR5發(fā)揮作用,在炎癥、感染、癌癥和免疫反應中扮演重要角色,其失調與多種自身免疫性疾病和腫瘤相關。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL,靈敏度為0.096 ng/mL。適用于基礎科研中探究感染性疾病、腫瘤免疫或自身免疫性疾病模型(如類風濕性關節(jié)炎、系統(tǒng)性紅斑狼瘡)的分子機制,亦可用于評估藥物干預或基因修飾對Cxcl13表達水平的影響,為免疫調控研究及生物標志物篩選提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Cxcl13 ELISA kit; Blc ELISA kit; Scyb13C-X-C motif chemokine 13 ELISA kit; B lymphocyte chemoattractant ELISA kit; CXC chemokine BLC ELISA kit; Small-inducible cytokine B13 ELISA kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates, cell culture supernates
  • 檢測范圍:
    0.156 ng/mL-10 ng/mL
  • 靈敏度:
    0.096 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

     Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess. 
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess. 
  • 線性度:

     To assess the linearity of the assay, samples were spiked with high concentrations of mouse Cxcl13/Blc/Scyb13 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標準曲線:

     These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 

  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

平均分:
4.0分 - 1 個評價

樣品類型:組織勻漿液 腫瘤勻漿

樣品信息:小鼠

稀釋比:其他 1:10

產(chǎn)品評價: 我們用CSB-E16832m檢測患病小鼠腫瘤勻漿中的CXCL13,樣本OD值為0.3-0.5

By 劉老師

靶點詳情

  • 最新研究進展:
    CXCL13也被稱為B淋巴細胞趨化素(BLC),是一種趨化因子蛋白,能夠在體內引起B(yǎng)細胞的化學趨化。最新的研究表明,CXCL13在免疫反應和疾病發(fā)展中起著重要作用。例如,CXCL13在淋巴組織結構形成、自身免疫疾病、腫瘤和傳染病等方面都有影響。此外,CXCL13也被證明是COVID-19患者中的一個重要因子,其濃度可以用于評估COVID-19的嚴重程度和預后。
  • 功能:
    Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
  • 基因功能參考文獻:
    1. CXCL13, upregulated by peripheral inflammation, acts on CXCR5 on dorsal root ganglia neurons and activates p38, which increases Nav1.8 current density and further contributes to the maintenance of inflammatory pain. PMID: 27708397
    2. This study indicated that CXCL13 may be pathogenically involved in Clostridium difficile infection (CDI) and served as a potential new biomarker for diagnosis and prognosis in CDI. PMID: 27685937
    3. CXCL13 has a role in directing B-lymphocyte migration PMID: 27477203
    4. CXCL13 and CXCR5 contribute to orofacial pain via ERK-mediated proinflammatory cytokines production. PMID: 27401148
    5. High glucose could inhibit osteogenic differentiation of mesenchymal stem cells by lncRNA AK028326 mediated down-regulation of CXCL13 expression. PMID: 27693963
    6. Data demonstrate that CXCL13 is not essential in mounting effective peripheral humoral responses, but specifically promotes CNS accumulation of differentiated B cells. PMID: 26795429
    7. overexpression of CXCL13 is associated with myasthenia gravis. PMID: 26771137
    8. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated benzo(a)pyrene-induced lung cancer in mice, demonstrating CXCL13's critical role in polycyclic aromatic hydrocarbon-induced lung carcinogenesis. PMID: 26565418
    9. Blockade of CXCL13 significantly reduced urine protein, serum creatinine, and dramatically attenuated renal pathology injury in lupus nephritis in mice. PMID: 26456520
    10. Results from this study suggest blockade of CXCL13 and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with Sjogren's syndrome PMID: 26826598
    11. findings reveal a neuronal/astrocytic interaction in the spinal cord by which neuronally produced CXCL13 activates astrocytes via CXCR5 to facilitate neuropathic pain. PMID: 26752644
    12. Study reports a novel role of AK141205/CXCL13 as a regulator of osteogenic growth peptide-induced osteogenic differentiation of smooth muscle cells. PMID: 26321662
    13. Data indicate that CXC chemokine CXCL13-responsive late transitional B cells are the initiating subset for the positive feedback loop. PMID: 25662995
    14. Study demonstrates that microglia are an important source of CXCL13 production in the acutely inflamed brain, and in vitro experiments confirm that type-I IFN selectively inhibits microglial production of CXCL13 in a dose-dependent manner PMID: 24829092
    15. Data suggest that Src homology 3 (SH3) protein interacting with NcK, 90 kDa (SPIN90)plays an important role in B cell immune responses through the regulation of chemokine CXCL13-mediated B cell migration. PMID: 24965518
    16. mediates vaccine-induced immunity against tuberculosis PMID: 23299616
    17. CXCL13 may be pathogenically involved in SS and may serve as a new marker and a potential therapeutic target. PMID: 23904442
    18. CXCL13 is produced within lymphoid follicles of patients with COPD and is crucial for the formation of TLOs. PMID: 23742729
    19. Late stage cathepsin C, CXCL13 and Ki-67 overexpression correlate with regional neuropathology in a bovine spongiform encephalopathy transgenic murine model. PMID: 22789860
    20. Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection. PMID: 23189125
    21. Data show that CXCL13/CXCR5 facilitated antigen encounter and BCR signaling by promoting membrane ruffling and LFA-1-supported adhesion require a functional actin cytoskeleton and the activity of the motor protein non-muscle myosin II (NM-II). PMID: 21659539
    22. LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. PMID: 21153342
    23. found enhanced plasma levels of CXCL13 in lupus-prone MRL/lpr and NZB/W-F1 mice PMID: 21084753
    24. Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues PMID: 20304952
    25. Disease-associated B lymphocyte selection into islets occurs despite CXCL13 blockade- induced disruption of their structural organization; loss of B cell organization in islets do not provide disease protection. PMID: 20574003
    26. elevated expression and different distribution in the aged spleen PMID: 19845796
    27. New putative control elements in the promoter OF CXCL13 chemokine gene, a target of alternative NF-kappaB pathway PMID: 19807029
    28. CXCL13 is essential for the spatial arrangement of lymphocytes within granulomas, optimal activation of phagocytes, and subsequent control of mycobacterial growth. PMID: 19933855
    29. A subset of dendritic cells expressing CXCR5 migrate rapidly into the primary lymphoid follicles from the marginal zone in response to CXC ligand 13 (B lymphocyte chemoattractant, CXCL13) via a B cell-derived, membrane lymphotoxin-dependent mechanism. PMID: 11994465
    30. CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. PMID: 12354388
    31. its aberrant high expression is a cause of SLE--review PMID: 12518463
    32. CXCL13 expressed in the high endothelial venule lumen plays a crucial role in B cell trafficking into secondary lymphoid tissues such as Peyer's patches. PMID: 12902460
    33. The tissue architecture of the lymphoid clusters induced in the chronic lesion of autoimmune gastritis is supported by a typical lymphoid reticular network and follicular dendritic cells expressing the B cell homing chemokine, CXC chemokine ligand 13. PMID: 14530361
    34. This experiment find that gene expression of CXCL13, a chemokine involved in B-cell recruitment into lymphoid follicles.the presence of lymphoid follicle-like structures containing B cells. PMID: 14975582
    35. data identify CXCL13 as an arrest chemokine for B cells in high endothelial venules and that CXCL13 plays an important role in B-cell entry into not only Peyer patches but also mesenteric lymph nodes PMID: 15972452
    36. B-cell defects in the nasal-associated lymphoid tissue of lymphotoxin(-/-) mice can be attributed to the impaired expression of CXCL13. PMID: 16210592
    37. double-negative (DN) Treg cells preferentially express Burkitt lymphoma receptor 1, and interaction of this chemokine receptor with its ligand CXCL13 plays an important role in DN Treg cell migration both in vitro and in vivo PMID: 16621993
    38. CXCL13 plays a pathogenic role in experimental autoimmune encephalomyelitis, particularly during the effector phase. PMID: 16751415
    39. ability of CXCL13 and sphingosine1-phosphate to direct the trafficking and localization of B cells in vivo may be dependent on Rap activation PMID: 16821235
    40. Pulmonary expression of Cxcl13 is essential for local immunity to influenza. PMID: 17563386
    41. study shows CCL21 & CXCL13 are transiently down-regulated in lymphoid tissues during immune responses by a mechanism controlled by interferon-gamma; the modulation altered localization of lymphocytes & dendritic cells within responding lymphoid tissues PMID: 17673664
    42. Survival after UVA irradiation was greater in human keratinocytes compared to mouse skin with no S100A2 expression, showing a protective role for S100A2. A S100A2-dependent difference was observed in the induction of Cxcl13 transcripts in transgenic mice. PMID: 18773213
    43. The activation of both canonical and non-canonical nuclear factor-kappaB (NF-kappaB) pathways was essential for CXCL13 induction. PMID: 19251935
    44. Unlike conventional lymphoid organs, milky spots in the omentum developed in the absence of lymphoid tissue-inducer cells, but required the chemokine CXCL13 PMID: 19427241
    45. RA induces CXCL13 expression and is essential for lymph node formation. PMID: 19783990

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine alpha (chemokine CxC) family
  • 組織特異性:
    Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).
  • 數(shù)據(jù)庫鏈接: