CXCR4
CXCR4：G蛋白耦聯(lián)受體（GPCR）家族，再出腫瘤免疫治療新藥！
趨化因子受體（C X C chemokine receptor 4，CXCR4）是一個(gè)具有7次跨膜結(jié)構(gòu)的G蛋白耦聯(lián)受體。CXCR4作為GPCR家族中的一員，GPCR的超家族群已經(jīng)被證明是許多藥物的藥理作用靶點(diǎn)。CXCR4在體內(nèi)大部分組織和器官上都有表達(dá)，包括骨髓、臍血和動(dòng)員的外周血來(lái)源的細(xì)胞表面，以及多種非造血干細(xì)胞表面表達(dá)。近年來(lái)研究發(fā)現(xiàn)，腫瘤細(xì)胞轉(zhuǎn)移到特定器官是不同器官通過趨化作用吸引特定類型腫瘤細(xì)胞歸巢的結(jié)果。在眾多的趨化因子受體中，CXCR4在許多腫瘤中都存在表達(dá)增強(qiáng)。目前的研究表明，與趨化因子受體CXCR4相關(guān)的癌癥超過23種，它還能促進(jìn)血管生成，細(xì)胞的轉(zhuǎn)移、生長(zhǎng)或生存。此外，還參與HIV病毒感染。這些生物學(xué)功能決定了CXCR4靶向藥可用于腫瘤、造血干細(xì)胞動(dòng)員、HIV等疾病的治療。
CUSABIO-哺乳包膜VLPs平臺(tái)成功開發(fā)CXCR4全長(zhǎng)膜蛋白（7次跨膜），展示了完整生物活性。
熱銷產(chǎn)品
Recombinant Human C-X-C chemokine receptor type 4(CXCR4)-VLPs (Active)（CSB-MP006254HU(F1)）
High Specificity Validated by Western Blot (WB)
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CSB-MP006254HU(F1) is detected by Mouse anti-6*His monoclonal antibody.
Excellent Bioactivity Validated by Functional ELISA
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Immobilized Human CXCR4 at 10 μg/ml can bind Anti-CXCR4 recombinant antibody (CSB-RA006254MA01HU), the EC50 is 101.7-253.6 ng/mL.
CXCR4 Antibodies
CXCR4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006254GA01HU | CXCR4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002588 | CXCR4 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA060127 | Phospho-CXCR4 (S339) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA006254YA01HU | CXCR4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA006254YB01HU | CXCR4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006254YC01HU | CXCR4 Antibody, FITC conjugated | Human | |
| CSB-PA006254YD01HU | CXCR4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA263860 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA996565 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA250029 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA099227 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA569311A0HU | CXCR4 Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-RA006254MA01HU | CXCR4 Recombinant Monoclonal Antibody | Human | ELISA |
CXCR4 Proteins
CXCR4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254MO1 CSB-EP006254MO1 CSB-BP006254MO1 CSB-MP006254MO1 CSB-EP006254MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254MO | Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4) | in vitro E.coli expression system |
CXCR4 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254MOW1 CSB-EP006254MOW1 CSB-BP006254MOW1 CSB-MP006254MOW1 CSB-EP006254MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254MOW | Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254BO1 CSB-EP006254BO1 CSB-BP006254BO1 CSB-MP006254BO1 CSB-EP006254BO1-B |
Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254BO | Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254CA1 CSB-EP006254CA1 CSB-BP006254CA1 CSB-MP006254CA1 CSB-EP006254CA1-B |
Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254CA | Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254RA1 CSB-EP006254RA1 CSB-BP006254RA1 CSB-MP006254RA1 CSB-EP006254RA1-B |
Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254RA | Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4) | in vitro E.coli expression system |
CXCR4 Proteins for Papio anubis (Olive baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254ERI1 CSB-EP006254ERI1 CSB-BP006254ERI1 CSB-MP006254ERI1 CSB-EP006254ERI1-B |
Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254ERI | Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254EQV1 CSB-EP006254EQV1 CSB-BP006254EQV1 CSB-MP006254EQV1 CSB-EP006254EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006254DRI1 CSB-EP006254DRI1 CSB-BP006254DRI1 CSB-MP006254DRI1 CSB-EP006254DRI1-B |
Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254DRI | Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP630683MOV1 CSB-EP630683MOV1 CSB-BP630683MOV1 CSB-MP630683MOV1 CSB-EP630683MOV1-B |
Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF630683MOV | Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP638935SH1 CSB-EP638935SH1 CSB-BP638935SH1 CSB-MP638935SH1 CSB-EP638935SH1-B |
Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF638935SH | Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP668610DO1 CSB-EP668610DO1 CSB-BP668610DO1 CSB-MP668610DO1 CSB-EP668610DO1-B |
Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF668610DO | Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP755226PI1 CSB-EP755226PI1 CSB-BP755226PI1 CSB-MP755226PI1 CSB-EP755226PI1-B |
Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF755226PI | Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Tupaia chinensis (Chinese tree shrew)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP768744TDAE1 CSB-EP768744TDAE1 CSB-BP768744TDAE1 CSB-MP768744TDAE1 CSB-EP768744TDAE1-B |
Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF768744TDAE | Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Saimiri sciureus (Common squirrel monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP810237SWD1 CSB-EP810237SWD1 CSB-BP810237SWD1 CSB-MP810237SWD1 CSB-EP810237SWD1-B |
Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF810237SWD | Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP818191CYL1 CSB-EP818191CYL1 CSB-BP818191CYL1 CSB-MP818191CYL1 CSB-EP818191CYL1-B |
Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF818191CYL | Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP886927DSU1 CSB-EP886927DSU1 CSB-BP886927DSU1 CSB-MP886927DSU1 CSB-EP886927DSU1-B |
Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886927DSU | Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-CF006254HU | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
| CSB-EP006254HU1 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
| CSB-EP006254HU1e0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
| CSB-MP006254HU | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs | Mammalian cell |
| CSB-MP006254HU(F1) | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs (Active) | Mammalian cell |
| CSB-EP006254HU1c0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
CXCR4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-CF006254HUa0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 ELISA Kit
CXCR4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12825h | Human CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
CXCR4 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12703r | Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
