CYBB
CYBB全稱為細胞色素b-245重鏈（Cytochrome b-245 heavy chain），又稱NOX2或gp91phox，是NADPH氧化酶復合物的核心催化亞基。CYBB主要分布于中性粒細胞、單核細胞等吞噬細胞的細胞膜上，負責催化氧分子生成超氧陰離子，構成機體抵抗病原微生物的關鍵防線。當免疫細胞識別入侵病原體時，CYBB蛋白會與多個調控亞基組裝形成活性酶復合體，通過"呼吸爆發(fā)"產生大量活性氧直接殺傷細菌，這一過程被稱為氧化殺菌作用。CYBB基因突變會導致慢性肉芽腫病（CGD），患者因無法有效清除病原體而反復發(fā)生嚴重感染，并伴隨肉芽腫形成和炎癥過度反應。針對該疾病的治療除了抗生素預防和干擾素-γ輔助治療外，干細胞基因治療已進入臨床試驗階段，通過回輸攜帶正常CYBB基因的造血干細胞實現功能修復?；贜OX2調控機制的抗氧化劑和抗炎藥物研究也為相關免疫缺陷及炎癥性疾病提供了新思路。
熱銷產品
Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial (CSB-EP006325HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CYBB Recombinant Monoclonal Antibody (CSB-RA006325MA1HU)
驗證數據
Immunofluorescence staining of hela cell with CSB-RA006325MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
CYBB Antibodies
CYBB for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006325KA01HU | CYBB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA006325LA01HU | CYBB Antibody | Human | ELISA, IHC, IF |
| CSB-PA006325LC01HU | CYBB Antibody, FITC conjugated | Human | |
| CSB-PA002737 | CYBB Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA005619 | CYBB Antibody | Human | WB, ELISA |
| CSB-PA176464 | CYBB Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA140004 | CYBB Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA006325MA1HU | CYBB Recombinant Monoclonal Antibody | Human | ELISA, IF |
CYBB Proteins
CYBB Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006325PI1 CSB-EP006325PI1 CSB-BP006325PI1 CSB-MP006325PI1 CSB-EP006325PI1-B |
Recombinant Pig Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006325PI | Recombinant Pig Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006325HU CSB-EP006325HU CSB-BP006325HU CSB-MP006325HU CSB-EP006325HU-B |
Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006325HU1 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | E.coli |
| CSB-CF006325HU | Recombinant Human Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
| CSB-EP006325HU1a2 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | E.coli |
| CSB-YP006325HU1 | Recombinant?Human?Cytochrome?b-245?heavy?chain (CYBB), partial | Yeast |
CYBB Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006325BO1 CSB-EP006325BO1 CSB-BP006325BO1 CSB-MP006325BO1 CSB-EP006325BO1-B |
Recombinant Bovine Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006325BO | Recombinant Bovine Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Escherichia coli (strain K12)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006306ENV1 CSB-EP006306ENV1 CSB-BP006306ENV1 CSB-MP006306ENV1 CSB-EP006306ENV1-B |
Recombinant Escherichia coli Cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006306ENV | Recombinant Escherichia coli Cytochrome b561 (cybB) | in vitro E.coli expression system |
CYBB Proteins for Shigella flexneri
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006306SZB1 CSB-EP006306SZB1 CSB-BP006306SZB1 CSB-MP006306SZB1 CSB-EP006306SZB1-B |
Recombinant Cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006306SZB | Recombinant Cytochrome b561 (cybB) | in vitro E.coli expression system |
CYBB Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP733771MO1 CSB-EP733771MO1 CSB-BP733771MO1 CSB-MP733771MO1 CSB-EP733771MO1-B |
Recombinant Mouse Cytochrome b-245 heavy chain (Cybb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF733771MO | Recombinant Mouse Cytochrome b-245 heavy chain (Cybb) | in vitro E.coli expression system |
CYBB Proteins for Bison bison (American bison) (Bos bison)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP836099BTE1 CSB-EP836099BTE1 CSB-BP836099BTE1 CSB-MP836099BTE1 CSB-EP836099BTE1-B |
Recombinant Bison bison Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF836099BTE | Recombinant Bison bison Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Yersinia pestis
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP893085YAS1 CSB-EP893085YAS1 CSB-BP893085YAS1 CSB-MP893085YAS1 CSB-EP893085YAS1-B |
Recombinant Probable cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF893085YAS | Recombinant Probable cytochrome b561 (cybB) | in vitro E.coli expression system |
