F3

F3，即組織因子，別名CD142、TF、TFA。它是由263個(gè)氨基酸殘基組成的跨膜單鏈糖蛋白，分子量約為47 kDa。F3的作用機(jī)制是通過與因子VII/VIIa結(jié)合啟動(dòng)血液凝固級(jí)聯(lián)反應(yīng)。它與細(xì)胞膜緊密結(jié)合，發(fā)揮“錨”作用，使生理性凝血過程局限于損傷部位。F3可以同時(shí)激活凝血因子Ⅸ和Ⅹ，啟動(dòng)內(nèi)、外源性兩種凝血酶聯(lián)放大反應(yīng)，在血栓形成過程中起著重要作用。然而，在生理濃度時(shí)，F(xiàn)3和FⅦ單獨(dú)存在都不具有促凝活性。F3在腫瘤患者中常伴有血液凝固性增強(qiáng)，并且在腫瘤組織中也常見血栓的形成，這可能與腫瘤血管內(nèi)皮細(xì)胞和腫瘤細(xì)胞上組織因子F3的異常高表達(dá)相關(guān)。F3的高表達(dá)直接影響細(xì)胞增殖、組織浸潤(rùn)性、轉(zhuǎn)移性等生物學(xué)特征，已成為腫瘤研究中頗具潛力的治療靶標(biāo)。

熱銷產(chǎn)品

Recombinant Human Tissue factor(F3),partial (Active) (CSB-MP007928HU2)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TF at 2 μg/ml can bind Anti-TF recombinant antibody (CSB-RA007928MA2HU). The EC₅₀ is 1.434-1.635 ng/mL.

The purity of F3 was greater than 95% as determined by SEC-HPLC

F3 Antibody

F3 Protein

F3 ELISA Kit

F3 Antibodies

F3 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007928LA01HU	F3 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA004263	F3 Antibody	Human,Monkey	WB, ELISA
CSB-PA005114	F3 Antibody	Human	WB, ELISA
CSB-PA008166	Phospho-F3 (S290) Antibody	Human	WB, IHC, ELISA
CSB-PA040718	F3 Antibody	Human	ELISA,WB,IHC
CSB-PA981490	F3 Antibody	Human	ELISA,IHC
CSB-RA776663A0HU	F3 Recombinant Monoclonal Antibody	Human, Rat	ELISA, WB, IHC

F3 Proteins

F3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-BP007928HU1 CSB-MP007928HU1 CSB-EP007928HU1-B	Recombinant Human Tissue factor (F3), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928HU	Recombinant Human Tissue factor (F3)	in vitro E.coli expression system
CSB-EP007928HU1	Recombinant Human Tissue factor (F3), partial	E.coli
CSB-EP007928HU(F2)	Recombinant Human Tissue factor (F3)	E.coli
CSB-MP007928HU2	Recombinant Human Tissue factor(F3),partial (Active)	Mammalian cell
CSB-MP007928HU-WD	Recombinant Human Tissue factor (F3), partial	Mammalian cell

F3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP007928MO1 CSB-EP007928MO1 CSB-BP007928MO1 CSB-EP007928MO1-B	Recombinant Mouse Tissue factor (F3), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF007928MO	Recombinant Mouse Tissue factor (F3)	in vitro E.coli expression system

F3 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP007928RB1 CSB-EP007928RB1 CSB-BP007928RB1 CSB-MP007928RB1 CSB-EP007928RB1-B	Recombinant Rabbit Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928RB	Recombinant Rabbit Tissue factor (F3)	in vitro E.coli expression system

F3 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP007928BO1 CSB-EP007928BO1 CSB-BP007928BO1 CSB-MP007928BO1 CSB-EP007928BO1-B	Recombinant Bovine Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928BO	Recombinant Bovine Tissue factor (F3)	in vitro E.coli expression system

F3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP686307MDAK CSB-EP686307MDAK CSB-BP686307MDAK CSB-MP686307MDAK CSB-EP686307MDAK-B	Recombinant Microplitis demolitor bracovirus I-Kappa-B like protein F2 (F3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

F3 Proteins for Cavia porcellus (Guinea pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP888355GU CSB-EP888355GU CSB-BP888355GU CSB-MP888355GU CSB-EP888355GU-B	Recombinant Guinea pig Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli