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HEPACAM

HEPACAM,全稱為肝細(xì)胞和星形膠質(zhì)細(xì)胞粘附分子,是一種廣泛表達(dá)于多種組織中的跨膜蛋白。該蛋白常見別名包括Hepatocellular Adhesion Molecule和Mucin-18等。HEPACAM主要通過與其他細(xì)胞表面分子相互作用,參與細(xì)胞粘附、遷移和信號傳導(dǎo)等過程。在腫瘤發(fā)生發(fā)展中,HEPACAM的表達(dá)異常與多種癌癥的侵襲和轉(zhuǎn)移密切相關(guān)。此外,該蛋白還與神經(jīng)系統(tǒng)疾病、心血管疾病等非腫瘤性疾病有關(guān)。近年來,針對HEPACAM的藥物研發(fā)取得了一定進(jìn)展,如義翹神州和MCE公司分別開發(fā)了重組人HEPACAM蛋白和HEPACAM蛋白(Human, HEK293, His),用于細(xì)胞運(yùn)動和腫瘤生長抑制等研究。賽業(yè)生物則構(gòu)建了Hepacam基因敲除小鼠模型,用于研究該基因在腫瘤抑制中的作用。隨著研究的深入,HEPACAM有望成為疾病診斷和治療的新的靶點(diǎn)。

熱銷產(chǎn)品

HEPACAM Antibody (CSB-PA010287LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA010287LA01HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: HEPACAM antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 41 kDa
Observed band size: 47 kDa

CSB-PA010287LA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA010287LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

HEPACAM Antibodies

HEPACAM for Homo sapiens (Human)

HEPACAM Proteins

HEPACAM Proteins for Homo sapiens (Human)