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ITGB4

整合素β4(ITGB4)是整合素家族成員,與α6亞基結(jié)合形成α6β4復(fù)合物,在細胞黏附和信號轉(zhuǎn)導(dǎo)中起關(guān)鍵作用。ITGB4也被稱為CD104,主要分布于上皮細胞半橋粒結(jié)構(gòu),負責(zé)錨定細胞與基底膜間的連接。ITGB4可通過激活PI3K和Ras通路參與細胞遷移及生存調(diào)控,其異常表達與多種侵襲性腫瘤密切相關(guān),如三陰性乳腺癌、胰腺癌中常出現(xiàn)ITGB4過表達,促進腫瘤轉(zhuǎn)移和耐藥性產(chǎn)生。ITGB4基因突變會導(dǎo)致交界型大皰性表皮松解癥,患者皮膚出現(xiàn)嚴重水皰病變。近年來針對該蛋白的藥物開發(fā)聚焦于單克隆抗體和肽類抑制劑,已有抗ITGB4人源化抗體(如ASC-06)進入臨床前研究,擬用于抑制腫瘤細胞侵襲。另有研究探索其與EGFR抑制劑聯(lián)用方案,旨在突破現(xiàn)有靶向治療的耐藥瓶頸。

熱銷產(chǎn)品

Recombinant Human Integrin beta-4 (ITGB4), partial (CSB-EP011887HU3)

驗證數(shù)據(jù)

CSB-EP011887HU3

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ITGB4 Recombinant Monoclonal Antibody (CSB-RA011887MA1HU)

驗證數(shù)據(jù)

CSB-RA011887MA1HU

Overlay Peak curve showing A549 cells surface stained with CSB-RA011887MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.

ITGB4 Antibodies

ITGB4 for Homo sapiens (Human)

ITGB4 Proteins

ITGB4 Proteins for Homo sapiens (Human)

ITGB4 Proteins for Mus musculus (Mouse)

ITGB4 Proteins for Rattus norvegicus (Rat)