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LILRA4

LILRA4全稱為白細胞免疫球蛋白樣受體亞家族A成員4,也被稱為ILT7或CD85g,屬于免疫球蛋白樣受體家族成員。LILRA4主要表達于漿細胞樣樹突狀細胞表面,通過與特定配體結合發(fā)揮免疫調節(jié)功能。LILRA4能識別病毒核酸復合物,在抗病毒免疫中通過調控I型干擾素分泌維持免疫平衡,其異常表達可能導致系統(tǒng)性紅斑狼瘡等自身免疫疾病的發(fā)生發(fā)展。LILRA4在腫瘤微環(huán)境中呈現(xiàn)差異性表達特征,與乳腺癌、淋巴瘤等惡性腫瘤的免疫逃逸現(xiàn)象存在關聯(lián)。近年針對LILRA4的藥物研發(fā)聚焦于調節(jié)其信號活性,包括開發(fā)靶向抗體和受體阻斷劑,其中部分候選藥物已進入臨床前研究階段。LILRA4與同家族成員LILRB4在功能上存在交叉性,這為開發(fā)廣譜免疫治療策略提供了新思路。

熱銷產品

LILRA4 Recombinant Monoclonal Antibody (CSB-RA012936MA1HU)

驗證數(shù)據(jù)

CSB-RA012936MA1HU

Western Blot Positive WB detected in:Hela whole cell lysate (20μg), HpeG2 whole cell lysate (20μg), Jurkat whole cell lysate (20μg), K562 whole cell lysate (20μg) All lanes: LILRA4 antibody at 1:1000 Secondary Goat polyclonal to human IgG at 1/40000 dilution Predicted band size:55.18, 47.81 kDa Observed band size:50 kDa Exposure time:20s

CSB-RA012936MA1HU

IHC image of CSB-RA012936MA1HU diluted at 1:100 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

LILRA4 Antibodies

LILRA4 for Homo sapiens (Human)

LILRA4 Proteins

LILRA4 Proteins for Homo sapiens (Human)