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  4. LILRA4 Recombinant Monoclonal Antibody

LILRA4 Recombinant Monoclonal Antibody

  • 中文名稱：
    LILRA4 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA012936MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot Positive WB detected in:Hela whole cell lysate (20μg), HpeG2 whole cell lysate (20μg), Jurkat whole cell lysate (20μg), K562 whole cell lysate (20μg) All lanes: LILRA4 antibody at 1:1000 Secondary Goat polyclonal to human IgG at 1/40000 dilution Predicted band size:55.18, 47.81 kDa Observed band size:50 kDa Exposure time:20s
    • IHC image of CSB-RA012936MA1HU diluted at 1:100 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA012936MA1HU LILRA4重組單克隆抗體是針對(duì)人白細(xì)胞免疫球蛋白樣受體A4（LILRA4）開發(fā)的高特異性科研工具。該抗體采用重組技術(shù)制備，可精準(zhǔn)識(shí)別LILRA4蛋白，該靶標(biāo)作為免疫調(diào)節(jié)受體家族成員，在髓系細(xì)胞中特異性表達(dá)，參與調(diào)控天然免疫應(yīng)答及炎癥反應(yīng)，與自身免疫性疾病、病毒感染等病理過程密切相關(guān)。經(jīng)嚴(yán)格驗(yàn)證，本產(chǎn)品在Western Blot實(shí)驗(yàn)中可識(shí)別重組表達(dá)及天然LILRA4蛋白，在1:500-1:2000稀釋范圍內(nèi)呈現(xiàn)清晰的特異性條帶；免疫組化應(yīng)用顯示其在1:50-1:200濃度下能有效定位石蠟包埋組織中LILRA4的細(xì)胞膜/胞質(zhì)分布，同時(shí)適用于ELISA檢測體系。該抗體具備優(yōu)異的批間一致性，適用于探索LILRA4在免疫細(xì)胞功能調(diào)控、疾病相關(guān)信號(hào)通路及腫瘤微環(huán)境中的作用機(jī)制，為免疫學(xué)研究、炎癥性疾病模型構(gòu)建及靶向治療策略開發(fā)提供可靠試劑支持，建議配合同源重組蛋白用于實(shí)驗(yàn)體系驗(yàn)證。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD85 antigen-like family member G antibody; CD85g antibody; ILT-7 antibody; ILT7 antibody; Immunoglobulin like transcript 7 antibody; Immunoglobulin-like transcript 7 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 4 antibody; LILRA4 antibody; LIRA4_HUMAN antibody; MGC129597 antibody; MGC129598 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LILRA4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    24F6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
  • 基因功能參考文獻(xiàn)：
    1. Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. PMID: 24586760
    2. ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs. PMID: 23401591
    3. Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
    4. the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells PMID: 12384430
    5. ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells. PMID: 16735691
    6. key regulator of human pDC function and interferon type I production. PMID: 18048391
    7. Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells. PMID: 19564354

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15503

    OMIM: 607517

    KEGG: hsa:23547

    STRING: 9606.ENSP00000291759

    UniGene: Hs.406708