PECAM1
血小板內(nèi)皮細(xì)胞黏附分子-1(PECAM1)又稱CD31或EndoCAM,是一種跨膜糖蛋白,主要表達(dá)于血管內(nèi)皮細(xì)胞、血小板及部分免疫細(xì)胞表面。PECAM1通過(guò)同源或異源分子結(jié)合介導(dǎo)細(xì)胞間黏附,參與調(diào)控血管通透性、炎癥反應(yīng)中白細(xì)胞的跨內(nèi)皮遷移以及血管生成過(guò)程。其胞內(nèi)段酪氨酸殘基磷酸化后可激活下游信號(hào),與PI3K/AKT、MAPK等通路存在關(guān)聯(lián),在維持血管穩(wěn)態(tài)中起關(guān)鍵作用。
PECAM1異常表達(dá)與動(dòng)脈粥樣硬化斑塊形成、血栓性疾病及腫瘤血管生成密切相關(guān)。在動(dòng)脈粥樣硬化中,其介導(dǎo)的單核細(xì)胞浸潤(rùn)加速斑塊進(jìn)展;在腫瘤微環(huán)境中則可能通過(guò)調(diào)控血管新生促進(jìn)癌癥轉(zhuǎn)移。目前針對(duì)PECAM1的治療策略多處于臨床前階段,包括開(kāi)發(fā)阻斷其介導(dǎo)白細(xì)胞遷移的單克隆抗體,以及利用其作為靶點(diǎn)構(gòu)建腫瘤血管靶向藥物遞送系統(tǒng)。
熱銷(xiāo)產(chǎn)品
PECAM1 Recombinant Monoclonal Antibody (CSB-RA017767MA1HU)
驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: THP-1 whole cell lysate, JK whole cell lysate
All lanes: PECAM1 antibody at 1:500
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 82-140 kDa
Observed band size: 140 kDa

Overlay Peak curve showing THP-1 cells stained with CSB-RA017767MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit (CSB-E08133h)
驗(yàn)證數(shù)據(jù)

貨號(hào):CSB-E08133h
規(guī)格:96T/48T
靈敏度:7.8 pg/mL
檢測(cè)范圍:31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
PECAM1 Antibodies
PECAM1 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
---|---|---|---|
CSB-PA017767GA01HU | PECAM1 Antibody | Human | ELISA,WB,IHC |
CSB-PA616412 | PECAM1 Antibody | Human | ELISA,WB |
CSB-PA116016 | PECAM1 (Ab-713) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA851852 | PECAM1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA666102 | Phospho-PECAM1 (Y713) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA777657 | PECAM1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA982317 | PECAM1 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA085447 | PECAM1 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA929097 | PECAM1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA022257 | PECAM1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA116222 | PECAM1 Antibody | Human | WB,ELISA |
CSB-PA017767LA01HU | PECAM1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
CSB-PA017767LB01HU | PECAM1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA017767LC01HU | PECAM1 Antibody, FITC conjugated | Human | |
CSB-PA017767LD01HU | PECAM1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA017767A0HU | CD31 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC |
CSB-MA017767A0m | CD31 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
CSB-RA017767MA1HU | PECAM1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, FC |
PECAM1 Proteins
PECAM1 Proteins for Bos taurus (Bovine)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP017767BO1 CSB-EP017767BO1 CSB-BP017767BO1 CSB-MP017767BO1 CSB-EP017767BO1-B |
Recombinant Bovine Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF017767BO | Recombinant Bovine Platelet endothelial cell adhesion molecule (PECAM1) | in vitro E.coli expression system |
PECAM1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP017767HU1 CSB-EP017767HU1 CSB-BP017767HU1 CSB-MP017767HU1 CSB-EP017767HU1-B |
Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF017767HU | Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1) | in vitro E.coli expression system |
PECAM1 Proteins for Rattus norvegicus (Rat)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP668776RA CSB-EP668776RA CSB-BP668776RA CSB-MP668776RA CSB-EP668776RA-B |
Recombinant Rat Platelet endothelial cell adhesion molecule (Pecam1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PECAM1 Proteins for Sus scrofa (Pig)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP839162PI CSB-EP839162PI CSB-BP839162PI CSB-MP839162PI CSB-EP839162PI-B |
Recombinant Pig Platelet endothelial cell adhesion molecule (PECAM1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PECAM1 ELISA Kit
PECAM1 ELISA Kit for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
---|---|---|---|
CSB-E08135m | Mouse soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma | 0.78 pg/mL |
PECAM1 ELISA Kit for Rattus norvegicus (Rat)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
---|---|---|---|
CSB-E08134r | Rat soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |
PECAM1 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類(lèi)型 | 靈敏度 |
---|---|---|---|
CSB-E08133h | Human soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit | serum, plasma, cell culture supernates | 7.8 pg/mL |