血小板激活因子受體（Platelet-Activating Factor Receptor，PAFR）是一種G蛋白偶聯(lián)受體，廣泛分布于血小板、中性粒細(xì)胞及血管內(nèi)皮細(xì)胞表面。該受體因介導(dǎo)炎癥級(jí)聯(lián)反應(yīng)而聞名，當(dāng)與配體PAF結(jié)合后，可觸發(fā)細(xì)胞內(nèi)鈣離子釋放并激活磷脂酶C，進(jìn)而促進(jìn)血管通透性增高、白細(xì)胞趨化及血小板活化。其異常活化與急性呼吸窘迫綜合征、過敏性休克、動(dòng)脈粥樣硬化等病理過程密切相關(guān)，在膿毒癥中常作為促炎介質(zhì)加劇全身炎癥反應(yīng)。
目前全球已開發(fā)多款PAFR拮抗劑，如昔帕芬旦（TCV-309）和來帕泛（Lexipafant）曾進(jìn)入敗血癥臨床試驗(yàn)，但因療效未達(dá)預(yù)期而終止。近年研究轉(zhuǎn)向該受體在腫瘤微環(huán)境中的作用，發(fā)現(xiàn)其通過調(diào)控NF-κB通路促進(jìn)乳腺癌轉(zhuǎn)移，相關(guān)小分子抑制劑正在臨床前評(píng)估中。某些抗組胺藥物被發(fā)現(xiàn)具有非特異性PAFR阻斷效應(yīng)，這為哮喘等過敏性疾病治療提供了新的聯(lián)合用藥思路。

熱銷產(chǎn)品

PTAFR Antibody (CSB-PA018946LA01HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: PTAFR antibody at 4µg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018946LA01HU at dilution of 1:100

Immunofluorescent analysis of A431 cells using CSB-PA018946LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunofluorescent analysis of HepG2 cells using CSB-PA018946LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)