QSOX1
QSOX1,全稱為Quiescin Sulfhydryl Oxidase 1,常見別名包括thiol oxidase 1。該蛋白在多種組織中廣泛表達(dá),尤其在胰腺、乳腺和免疫細(xì)胞等分泌旺盛的細(xì)胞中活性較高。QSOX1參與蛋白質(zhì)的正確折疊,幫助新生蛋白質(zhì)形成正確的二硫鍵結(jié)構(gòu),維持蛋白質(zhì)的穩(wěn)定性和功能。此外,QSOX1還涉及細(xì)胞外基質(zhì)的重塑、細(xì)胞遷移和粘附等過程。
QSOX1的異常表達(dá)與多種疾病相關(guān),包括癌癥、神經(jīng)退行性疾病和纖維化疾病。在腫瘤中,QSOX1常出現(xiàn)過表達(dá),促進(jìn)腫瘤細(xì)胞的侵襲和轉(zhuǎn)移。QSOX1的表達(dá)水平異常也與某些癌癥的耐藥性相關(guān)。相反,QSOX1表達(dá)降低可能導(dǎo)致蛋白質(zhì)折疊異常,引發(fā)內(nèi)質(zhì)網(wǎng)應(yīng)激,甚至細(xì)胞凋亡。QSOX1的突變可能影響其酶活性,導(dǎo)致二硫鍵形成障礙,進(jìn)而影響依賴其功能的蛋白質(zhì)的穩(wěn)定性。QSOX1在維持蛋白質(zhì)穩(wěn)態(tài)和細(xì)胞功能中起關(guān)鍵作用,其表達(dá)水平的異常與多種病理過程密切相關(guān),使其成為潛在的疾病治療靶點。目前,針對QSOX1的藥物研發(fā)正在積極進(jìn)行中,以期找到治療癌癥、神經(jīng)退行性疾病等疾病的新方法。
熱銷產(chǎn)品
Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial (CSB-EP019144HU1)
驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
QSOX1 Antibody (CSB-PA019144LA01HU)
驗證數(shù)據(jù)

Western Blot
Positive WB detected in: Hela whole cell lysate, Rat heart tissue
All lanes: QSOX1 antibody at 5.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 83 kDa
Observed band size: 83 kDa

IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Sulfhydryl oxidase 1(QSOX1) ELISA kit (CSB-EL019144HU)
驗證數(shù)據(jù)

貨號:CSB-EL019144HU
規(guī)格:96T/48T
靈敏度:3.9 pg/mL
檢測范圍:15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
QSOX1 Antibodies
QSOX1 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA019144GA01HU | QSOX1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA019144LA01HU | QSOX1 Antibody | Human, Rat | ELISA, WB, IHC |
CSB-PA019144LB01HU | QSOX1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA019144LC01HU | QSOX1 Antibody, FITC conjugated | Human | |
CSB-PA019144LD01HU | QSOX1 Antibody, Biotin conjugated | Human | ELISA |
QSOX1 Proteins
QSOX1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP019144HU1 CSB-BP019144HU1 CSB-MP019144HU1 CSB-EP019144HU1-B |
Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF019144HU | Recombinant Human Sulfhydryl oxidase 1 (QSOX1) | in vitro E.coli expression system |
CSB-EP019144HU1 | Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial | E.coli |
QSOX1 ELISA Kit
QSOX1 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL019144HU | Human Sulfhydryl oxidase 1(QSOX1) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |