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QSOX1

QSOX1,全稱為Quiescin Sulfhydryl Oxidase 1,常見別名包括thiol oxidase 1。該蛋白在多種組織中廣泛表達(dá),尤其在胰腺、乳腺和免疫細(xì)胞等分泌旺盛的細(xì)胞中活性較高。QSOX1參與蛋白質(zhì)的正確折疊,幫助新生蛋白質(zhì)形成正確的二硫鍵結(jié)構(gòu),維持蛋白質(zhì)的穩(wěn)定性和功能。此外,QSOX1還涉及細(xì)胞外基質(zhì)的重塑、細(xì)胞遷移和粘附等過程。
QSOX1的異常表達(dá)與多種疾病相關(guān),包括癌癥、神經(jīng)退行性疾病和纖維化疾病。在腫瘤中,QSOX1常出現(xiàn)過表達(dá),促進(jìn)腫瘤細(xì)胞的侵襲和轉(zhuǎn)移。QSOX1的表達(dá)水平異常也與某些癌癥的耐藥性相關(guān)。相反,QSOX1表達(dá)降低可能導(dǎo)致蛋白質(zhì)折疊異常,引發(fā)內(nèi)質(zhì)網(wǎng)應(yīng)激,甚至細(xì)胞凋亡。QSOX1的突變可能影響其酶活性,導(dǎo)致二硫鍵形成障礙,進(jìn)而影響依賴其功能的蛋白質(zhì)的穩(wěn)定性。QSOX1在維持蛋白質(zhì)穩(wěn)態(tài)和細(xì)胞功能中起關(guān)鍵作用,其表達(dá)水平的異常與多種病理過程密切相關(guān),使其成為潛在的疾病治療靶點。目前,針對QSOX1的藥物研發(fā)正在積極進(jìn)行中,以期找到治療癌癥、神經(jīng)退行性疾病等疾病的新方法。

熱銷產(chǎn)品

Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial (CSB-EP019144HU1)

驗證數(shù)據(jù)

CSB-EP019144HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

QSOX1 Antibody (CSB-PA019144LA01HU)

驗證數(shù)據(jù)

CSB-PA019144LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, Rat heart tissue
All lanes: QSOX1 antibody at 5.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 83 kDa
Observed band size: 83 kDa

CSB-PA019144LA01HU

IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA019144LA01HU

IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Sulfhydryl oxidase 1(QSOX1) ELISA kit (CSB-EL019144HU)

驗證數(shù)據(jù)

CSB-EL019144HU 標(biāo)準(zhǔn)曲線

貨號:CSB-EL019144HU

規(guī)格:96T/48T

靈敏度:3.9 pg/mL

檢測范圍:15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

QSOX1 Antibodies

QSOX1 for Homo sapiens (Human)

QSOX1 Proteins

QSOX1 Proteins for Homo sapiens (Human)

QSOX1 ELISA Kit

QSOX1 ELISA Kit for Homo sapiens (Human)