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RFWD2

E3 ubiquitin-protein ligase RFWD2 is a protein in humans that is encoded by RFWD2 gene. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes.

RFWD2 Antibodies

RFWD2 for Homo sapiens (Human)

RFWD2 Proteins

RFWD2 Proteins for Homo sapiens (Human)

RFWD2 Proteins for Mus musculus (Mouse)

RFWD2 Proteins for Homo sapiens(Human)