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S100A4

S100A4蛋白全稱為鈣結(jié)合蛋白S100A4,也被稱為轉(zhuǎn)移素或p9Ka,是一種多功能小分子蛋白。它通過與細(xì)胞內(nèi)不同靶點(diǎn)結(jié)合,影響細(xì)胞骨架動態(tài)變化,促進(jìn)細(xì)胞運(yùn)動及侵襲能力,尤其在腫瘤轉(zhuǎn)移過程中扮演關(guān)鍵角色。S100A4常與乳腺癌、結(jié)直腸癌等多種惡性腫瘤的侵襲性生長和遠(yuǎn)端擴(kuò)散密切相關(guān),其高表達(dá)常提示患者預(yù)后不良。此外,在肺纖維化、類風(fēng)濕性關(guān)節(jié)炎等慢性疾病中,S100A4也被發(fā)現(xiàn)參與組織異常重塑和炎癥反應(yīng)調(diào)控。
近年來研究發(fā)現(xiàn),抑制S100A4功能可有效減緩腫瘤轉(zhuǎn)移進(jìn)程。多個(gè)研究團(tuán)隊(duì)正在開發(fā)針對該蛋白的小分子抑制劑和單克隆抗體,其中部分化合物已在動物模型中顯示出阻斷癌細(xì)胞遷移的效果。某些已上市藥物如二甲雙胍被發(fā)現(xiàn)具有間接調(diào)控S100A4表達(dá)的作用,這為老藥新用提供了潛在方向。學(xué)術(shù)界與制藥企業(yè)正通過結(jié)構(gòu)生物學(xué)手段解析其三維構(gòu)象,以期設(shè)計(jì)出更精準(zhǔn)的靶向治療藥物。

熱銷產(chǎn)品

Recombinant Human Protein S100-A4 (S100A4) (CSB-EP020632HU)

驗(yàn)證數(shù)據(jù)

CSB-EP020632HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

S100A4 Antibody (CSB-PA020632HA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA020632HA01HU

Western blot
All lanes: S100A4 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa

CSB-PA020632HA01HU

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA020632HA01HU

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

S100A4 Antibodies

S100A4 for Homo sapiens (Human)

S100A4 Proteins

S100A4 Proteins for Homo sapiens (Human)

S100A4 Proteins for Bos taurus (Bovine)

S100A4 Proteins for Rattus norvegicus (Rat)

S100A4 Proteins for Mus musculus (Mouse)

S100A4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

S100A4 ELISA Kit

S100A4 ELISA Kit for Homo sapiens (Human)

S100A4 ELISA Kit for Mus musculus (Mouse)