SYNJ2BP
SYNJ2BP，全稱為Synaptojanin 2 Binding Protein，在神經(jīng)元中高度表達(dá)，尤其在突觸前末端，對維持突觸結(jié)構(gòu)和功能穩(wěn)定性至關(guān)重要。該蛋白通過與Synaptojanin 2（SYNJ2）相互作用，影響磷酸肌醇代謝，從而調(diào)節(jié)神經(jīng)遞質(zhì)釋放和突觸傳遞效率。SYNJ2BP的異常表達(dá)可能影響突觸囊泡的循環(huán)，導(dǎo)致神經(jīng)信號傳遞異常。若該基因過表達(dá)，可能干擾正常的突觸可塑性，影響學(xué)習(xí)與記憶功能；而表達(dá)降低則可能導(dǎo)致突觸退化，加劇神經(jīng)退行性病變。SYNJ2BP還可能通過影響線粒體功能間接調(diào)控神經(jīng)元存活。其表達(dá)水平的變化可能影響其他突觸相關(guān)基因（如SYNJ2、DNM1）的功能，進(jìn)一步干擾神經(jīng)網(wǎng)絡(luò)的穩(wěn)定性。
SYNJ2BP的異常表達(dá)可能影響突觸囊泡的循環(huán)，導(dǎo)致神經(jīng)信號傳遞異常，進(jìn)而與神經(jīng)退行性疾?。ㄈ绨柎暮Ｄ。┖途裾系K（如精神分裂癥）有一定關(guān)聯(lián)。目前針對SYNJ2BP的研究仍在深入，以明確其在神經(jīng)系統(tǒng)疾病中的具體作用機制。
熱銷產(chǎn)品
SYNJ2BP Antibody (CSB-PA023018LA01HU)
驗證數(shù)據(jù)
Immunoprecipitating SYNJ2BP in Rat kidney tissue
Lane 1: Rabbit control IgG instead of CSB-PA023018LA01HU in Rat kidney tissue. For western blotting, a HRP-conjugated light chain specific antibody was used as the secondary antibody (1/50000)
Lane 2: CSB-PA023018LA01HU (6µg) + Rat kidney tissue (500µg)
Lane 3: Rat kidney tissue (20µg)
Western blot
All lanes: SYNJ2BP antibody at 3µg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: U251 whole cell lysate
Lane 3: Caco-2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023018LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA023018LA01HU at dilution of 1:100
Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: SYNJ2BP antibody at 2.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa
Immunohistochemistry analysis of human liver cancer using CSB-PA023018LA01HU at dilution of 1:100
SYNJ2BP Antibodies
SYNJ2BP for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023018GA01HU | SYNJ2BP Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA023018LA01HU | SYNJ2BP Antibody | Human, Rat | ELISA, WB, IHC, IP |
| CSB-PA023018LB01HU | SYNJ2BP Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023018LC01HU | SYNJ2BP Antibody, FITC conjugated | Human |
SYNJ2BP Proteins
SYNJ2BP Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023018HU CSB-EP023018HU CSB-BP023018HU CSB-MP023018HU CSB-EP023018HU-B |
Recombinant Human Synaptojanin-2-binding protein (SYNJ2BP) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
