TWIST1
TWIST1，即扭曲螺旋轉(zhuǎn)錄因子1，別名TWIST、TWISTL1等。它是一種由TWIST1基因編碼的轉(zhuǎn)錄因子，屬于基本螺旋-環(huán)-螺旋(bHLH)超家族成員，在多種組織中表達(dá)。TWIST1的作用機(jī)制主要是通過結(jié)合到特定DNA序列上的E-box元件，調(diào)控下游基因的表達(dá)，影響細(xì)胞的增殖、分化和遷移。TWIST1的異常表達(dá)與多種疾病有關(guān)，尤其是在癌癥中，TWIST1的高表達(dá)與腫瘤的侵襲性、轉(zhuǎn)移和預(yù)后不良相關(guān)。TWIST1能夠促進(jìn)上皮-間充質(zhì)轉(zhuǎn)化(EMT)，增強(qiáng)腫瘤細(xì)胞的侵襲和轉(zhuǎn)移能力。因此，TWIST1是腫瘤研究和治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
TWIST1 Antibody (CSB-PA944996)
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from JK, Raji and HL-60 cells using Twist1 Antibody.
Twist1 Antibody staining Twist in Mouse pancreatic cancer tissue sections by Immunohistochemistry
TWIST1 Antibodies
TWIST1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025358GA01HU | TWIST1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA944996 | TWIST1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA245152 | TWIST1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA084858 | TWIST1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA025358LA01HU | TWIST1 Antibody | Human | ELISA, WB |
| CSB-PA025358LB01HU | TWIST1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025358LC01HU | TWIST1 Antibody, FITC conjugated | Human | |
| CSB-PA025358LD01HU | TWIST1 Antibody, Biotin conjugated | Human | ELISA |
TWIST1 Proteins
TWIST1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP613599HU CSB-EP613599HU CSB-BP613599HU CSB-MP613599HU CSB-EP613599HU-B |
Recombinant Human Twist-related protein 1 (TWIST1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
