ZG16B
ZG16B，即酶原顆粒蛋白16同源物B。別名PAUF、JCLN2、HRPE773、PRO1567。ZG16B是一種含有一個(gè)p-棱鏡結(jié)構(gòu)的哺乳動(dòng)物凝集素，具有調(diào)節(jié)細(xì)胞黏附、轉(zhuǎn)移、凋亡、血管生成以及細(xì)胞與細(xì)胞間相互作用來(lái)識(shí)別病原體的能力。ZG16B的作用機(jī)制涉及激活多種信號(hào)通路，如CXCR4、β-catenin、TPL2/MEK/ERK、FAK/Scr等，促進(jìn)腫瘤細(xì)胞的遷移和血管生成。ZG16B在多種腫瘤中異常表達(dá)，尤其是在胰腺癌中高表達(dá)，對(duì)腫瘤細(xì)胞的增殖、粘附、遷移、侵襲起著重要作用，使其成為具有潛力的腫瘤診斷生物標(biāo)記物和治療靶點(diǎn)。目前，已有多款針對(duì)ZG16B的抗體藥物處于臨床階段，主要用于胰腺癌和卵巢癌治療，顯示了其在腫瘤治療中的潛力和重要性。
熱銷產(chǎn)品
Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active) (CSB-MP836195HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B at 2 μg/ml can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU), the EC50 is 24.13-46.04 ng/mL.
The purity of ZG16B was greater than 95% as determined by SEC-HPLC
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B at 2μg/mL can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU)， the EC50 is 20.15-28.98 ng/mL.
ZG16B Recombinant Monoclonal Antibody (CSB-RA836195MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human ZG16B with Anti-ZG16B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B (CSB-MP836195HU) at 2 μg/mL can bind Anti-ZG16B recombinant antibody, the EC50 is 24.13-46.04 ng/mL.
The Binding Activity of Macaca fascicularis ZG16B with Anti-ZG16B recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B (CSB-MP4727MOV) at 2 μg/mL can bind Anti-ZG16B recombinant antibody , the EC50 is 20.15-28.98 ng/mL.
ZG16B Antibodies
ZG16B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-RA836195MA1HU | ZG16B Recombinant Monoclonal Antibody | Human, Macaca fascicularis | ELISA |
ZG16B Proteins
ZG16B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP836195HU | Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) | Yeast |
| CSB-EP836195HU | Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) | E.coli |
| CSB-BP836195HU CSB-EP836195HU-B |
Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP836195HU | Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) (Active) | Mammalian cell |
| CSB-MP836195HUd9 | Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B) | Mammalian cell |
