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ZG16B Recombinant Monoclonal Antibody

  • 中文名稱：
    ZG16B重組抗體
  • 貨號(hào)：
    CSB-RA836195MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human ZG16B with Anti-ZG16B recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B (CSB-MP836195HU) at 2 μg/mL can bind Anti-ZG16B recombinant antibody, the EC50 is 24.13-46.04 ng/mL.
    • The Binding Activity of Macaca fascicularis ZG16B with Anti-ZG16B recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B (CSB-MP4727MOV) at 2 μg/mL can bind Anti-ZG16B recombinant antibody , the EC50 is 20.15-28.98 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA836195MA1HU為ZG16B重組單克隆抗體，靶向人源ZG16B（Zymogen Granule Protein 16B）蛋白，該蛋白在消化酶分泌調(diào)控中發(fā)揮重要作用，參與胰腺酶原顆粒的形成及腸道免疫調(diào)節(jié)過程。本產(chǎn)品經(jīng)過嚴(yán)格的ELISA平臺(tái)驗(yàn)證，展現(xiàn)出優(yōu)異的結(jié)合特異性和檢測(cè)靈敏度，不同批次間具有高度穩(wěn)定性，可精準(zhǔn)識(shí)別天然構(gòu)象及重組表達(dá)的ZG16B靶蛋白。適用于體外檢測(cè)ZG16B蛋白表達(dá)水平，支持消化系統(tǒng)功能研究、分泌通路機(jī)制解析以及腸道屏障相關(guān)疾病的分子機(jī)理探索，為研究腸道微生物互作、細(xì)胞粘附調(diào)控及外分泌細(xì)胞功能提供可靠工具。該抗體適用于樣本中ZG16B的定量檢測(cè)與定性分析，廣泛應(yīng)用于細(xì)胞模型、組織裂解液等實(shí)驗(yàn)體系的基礎(chǔ)科研領(lǐng)域。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ZG16B; Zymogen granule protein 16 homolog B; UNQ773/PRO1567
  • 反應(yīng)種屬：
    Human, Macaca fascicularis
  • 免疫原：
    Recombinant Human ZG16B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    6E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells PMID: 27322081
    2. Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. PMID: 28988106
    3. Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma PMID: 27706833
    4. High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. PMID: 26684804
    5. PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 PMID: 26336989
    6. constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection PMID: 25727013
    7. PAUF rs12373A>C polymorphisms are associated with colorectal cancer. PMID: 25079514
    8. PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. PMID: 23677445
    9. new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases PMID: 22907431
    10. activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. PMID: 22640743
    11. PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. PMID: 21464589
    12. PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. PMID: 21196815
    13. Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. PMID: 20858015
    14. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
    15. PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. PMID: 20802527
    16. Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. PMID: 19784070
    17. Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. PMID: 16954406
    18. pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated PMID: 19302292

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Jacalin lectin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30456

    KEGG: hsa:124220

    STRING: 9606.ENSP00000371715

    UniGene: Hs.105887