Perfringolysin O (PFO)是由肉毒梭菌（Clostridium perfringens）產(chǎn)生的毒素。其結(jié)構(gòu)是一個(gè)大的單亞單位蛋白，具有約497個(gè)氨基酸，含有多個(gè)β-折疊和α螺旋結(jié)構(gòu)。PFO主要通過與細(xì)胞膜中的膽固醇結(jié)合，形成聚合物，并形成可通透的孔道，導(dǎo)致細(xì)胞膜的破壞和溶解。這種溶孔作用會破壞細(xì)胞的完整性，導(dǎo)致溶解和細(xì)胞死亡。PFO主要通過膽固醇結(jié)合并引發(fā)細(xì)胞膜的溶解，導(dǎo)致細(xì)胞內(nèi)外離子平衡失調(diào)，從而影響細(xì)胞的生存和功能。PFO和其變體可以用作生物學(xué)研究中的細(xì)胞膜溶解工具，用于探究細(xì)胞膜通透性和細(xì)胞膜受損的影響。在肉毒梭菌感染的情況下，PFO被認(rèn)為是該菌致病性的重要因素之一，它參與了細(xì)胞的溶解和組織損傷，因此在了解和研究感染機(jī)制、藥物開發(fā)等方面有一定的應(yīng)用價(jià)值。

熱銷產(chǎn)品

Recombinant Clostridium perfringens Perfringolysin O (pfo)

驗(yàn)證數(shù)據(jù)

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS Analysis result of CSB-EP314820CMB could indicate that this peptide derived from E.coli-expressed Clostridium perfringens (strain 13 / Type A) pfo.

LC-MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS Analysis result of CSB-EP314820CMB could indicate that this peptide derived from E.coli-expressed Clostridium perfringens (strain 13 / Type A) pfo.