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  4. Human Bone morphogenetic protein 8A(BMP8A) ELISA kit

Human Bone morphogenetic protein 8A(BMP8A) ELISA kit

  • 中文名稱：
    人骨形態(tài)發(fā)生蛋白8A(BMP8A)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL002745HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人骨形態(tài)發(fā)生蛋白8A(BMP8A)酶聯(lián)免疫試劑盒（CSB-EL002745HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的BMP8A含量。BMP8A 是一種骨形態(tài)發(fā)生蛋白。其背景上，在胚胎發(fā)育等生理過程中可能發(fā)揮作用。研究機制方面，可能參與調(diào)節(jié)細胞的增殖、分化等。它或許與骨組織形成、代謝相關(guān)，對其深入研究有助于揭示相關(guān)生理病理機制以及開發(fā)治療靶點。試劑盒檢測范圍為37.5 pg/mL-2400 pg/mL，科研人員可將其應(yīng)用于骨骼發(fā)育機制研究、組織修復(fù)模型構(gòu)建、生殖生物學(xué)探索以及代謝相關(guān)疾?。ㄈ绶逝?、糖尿病）的分子機制解析，為體外實驗、動物模型或人類樣本中的BMP8A功能研究提供高效工具，助力基礎(chǔ)醫(yī)學(xué)、細胞生物學(xué)及發(fā)育生物學(xué)等領(lǐng)域的科研突破。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    BMP-8A ELISA Kit; BMP8 ELISA Kit; Bmp8a ELISA Kit; BMP8A_HUMAN ELISA Kit; Bone morphogenetic protein 8A ELISA Kit; FLJ14351 ELISA Kit; FLJ45264 ELISA Kit; OP 2 ELISA Kit; Osteogenic protein 2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    37.5 pg/mL-2400 pg/mL
  • 靈敏度：
    9.38 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Stem Cells
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway.
  • 基因功能參考文獻：
    1. Authors found that Bmp8a, but not Bmp8b, was expressed predominantly in the neonatal mouse spermatogonia. Although most BMPs induce activation of SMADs 1, 5, and 8 (SMAD1/5/8), but not SMADs 2 and 3 (SMAD2/3), they found that BMP8A induced signaling through both sets of transcription factors. PMID: 28465413
    2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20424473
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21650

    KEGG: hsa:353500

    STRING: 9606.ENSP00000327440

    UniGene: Hs.472497